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| Open AccessMDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia
- Ada Lerma Clavero
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| Open AccessRemdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
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| Open AccessKinin B1 and B2 receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors
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| Open AccessTranscranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model
- Evgenii Kim
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| Open AccessBased on network pharmacology and bioinformatics to analyze the mechanism of action of Astragalus membranaceus in the treatment of vitiligo and COVID-19
- Yaojun Wang
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| Open AccessInteraction of hemorphins with ACE homologs
- Amie Jobe
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| Open AccessAlleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4
- Chandru Gajendran
- , Shoichi Fukui
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| Open AccessAdvances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant
- J.-D. Masson
- , G. Badran
- & G. Crépeaux
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| Open AccessProtective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A
- Pensiri Buacheen
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- & Pornsiri Pitchakarn
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| Open AccessProtective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate
- Zhizheng Fang
- , Xiangyu Li
- & Rongchun Han
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| Open AccessApplication of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease
- Sundus Khalid
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- & Faleh Alqahtani
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| Open AccessA validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract
- Phanit Songvut
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| Open AccessPien Tze Huang regulates phosphorylation of metabolic enzymes in mice of hepatocellular carcinoma
- Jinxia Lin
- , Shicong Wang
- & Mei Li
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| Open AccessPRMT5 is a therapeutic target in choroidal neovascularization
- Anbukkarasi Muniyandi
- , Matthew Martin
- & Timothy W. Corson
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| Open AccessSynergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells
- Nur Aininie Yusoh
- , Suet Lin Chia
- & Martin R. Gill
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| Open AccessDevelopmental changes in the extent of drug binding to rat plasma proteins
- Fiona Qiu
- , Katarzyna M. Dziegielewska
- & Norman R. Saunders
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| Open AccessHuman osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling
- Arundhasa Chandrabalan
- , Andrew Firth
- & Rithwik Ramachandran
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| Open AccessA rodent model for Dirofilaria immitis, canine heartworm: parasite growth, development, and drug sensitivity in NSG mice
- Jessica A. Hess
- , Mark L. Eberhard
- & David Abraham
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| Open AccessSex-dependent effects of canagliflozin and dapagliflozin on hemostasis in normoglycemic and hyperglycemic mice
- Natalia Marcińczyk
- , Tomasz Misztal
- & Anna Gromotowicz-Popławska
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| Open AccessEffect of date molasses on levetiracetam pharmacokinetics in healthy rats
- Wael Abu Dayyih
- , Raghad Layth
- & Saed M. Aldalaen
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| Open AccessEstablishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs
- Ryu Kawada
- , Tatsuya Jonouchi
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| Open AccessIL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH
- Dániel Kucsera
- , Viktória E. Tóth
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| Open AccessEffects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy
- Ashley N. Sharpe
- , Maureen S. Oldach
- & Joshua A. Stern
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| Open AccessEffects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor
- Vidya Perera
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| Open AccessIntegration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities
- Indeewarie H. Dissanayake
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- & Dinithi C. Peiris
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| Open AccessFerroptosis inhibition by deferiprone, attenuates myelin damage and promotes neuroprotection in demyelinated optic nerve
- Atefeh Rayatpour
- , Forough Foolad
- & Mohammad Javan
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| Open AccessAllyl ether of mansonone G as a potential anticancer agent for colorectal cancer
- Savinee Chanvijit
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- & Piyanuch Wonganan
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| Open AccessInfluence of tramadol on bacterial burden in the standard neutropenic thigh infection model
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| Open AccessSafety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs
- Laura Cresti
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| Open AccessIsolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment
- Dharmar Manimaran
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| Open AccessA randomized pharmacological fMRI trial investigating d-cycloserine and brain plasticity mechanisms in learned pain responses
- Mia A. Thomaidou
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| Open AccessRemimazolam besylate for the sedation of postoperative patients undergoing invasive mechanical ventilation in the ICU: a prospective dose‒response study
- Xiaoyan Chen
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| Open AccessExpression of membrane Hsp90 is a molecular signature of T cell activation
- Scott A. Scarneo
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| Open AccessEpigallocatechin gallate (EGCG) alleviates vascular dysfunction in angiotensin II-infused hypertensive mice by modulating oxidative stress and eNOS
- Nurul Aiza Mohd Sabri
- , Siew-Keah Lee
- & Wei Chih Ling
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| Open AccessNT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
- Lívia Bassani Lins de Miranda
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| Open AccessA novel glucagon analog with an extended half-life, HM15136, normalizes glucose levels in rodent models of congenital hyperinsulinism
- Yong Ho Heo
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| Open AccessAlloferon-1 ameliorates acute inflammatory responses in λ-carrageenan-induced paw edema in mice
- Xiangrui Zhang
- , Vladimir Retyunskiy
- & Chi-Meng Tzeng
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| Open AccessInfluence of Huangqin Decoction on the immune function and fecal microbiome of chicks after experimental infection with Escherichia coli O78
- Junyan Wang
- , Rui Li
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| Open AccessIonic complexation improves wound healing in deep second-degree burns and reduces in-vitro ciprofloxacin cytotoxicity in fibroblasts
- María Florencia Sanchez
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| Open AccessFASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models
- Marie O’Farrell
- , Greg Duke
- & George Kemble
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| Open AccessNovel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
- Sven Ruf
- , Sridharan Rajagopal
- & Aimo Kannt
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| Open AccessActivation of SIRT1 promotes membrane resealing via cortactin
- Naotoshi Iwahara
- , Kuya Azekami
- & Atsushi Kuno
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| Open AccessConstruction of a culture protocol for functional bile canaliculi formation to apply human iPS cell-derived hepatocytes for cholestasis evaluation
- Shinichiro Horiuchi
- , Yukie Kuroda
- & Seiichi Ishida
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| Open AccessImpact of intravenous dexmedetomidine on gastrointestinal function recovery after laparoscopic hysteromyomectomy: a randomized clinical trial
- Yu Wu
- , Zenghua Cai
- & Ni An
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| Open AccessAlpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models
- Eunhye Yu
- , Yunjeong Song
- & Jaesuk Yun
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| Open AccessHerb-anticancer drug interactions in real life based on VigiBase, the WHO global database
- Stéphanie Pochet
- , Anne-Sophie Lechon
- & Florence Souard
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| Open AccessEicosapentaenoic acid (EPA)-induced inhibitory effects on porcine coronary and cerebral arteries involve inhibition of prostanoid TP receptors
- Kento Yoshioka
- , Keisuke Obara
- & Yoshio Tanaka
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| Open AccessOptimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
- Andrew A. Bieberich
- , Tuomo Laitinen
- & Christopher R. M. Asquith