Receptor pharmacology articles within Scientific Reports

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• Article
  27 April 2024 | Open Access

  Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies

  • Shinsuke Nakamura
  • , Rie Yamamoto
  •  & Hideaki Hara

• Article
  08 April 2024 | Open Access

  DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

  • Michael Kurz
  • , Michaela Ulrich
  •  & Moritz Bünemann

• Article
  28 January 2024 | Open Access

  Kv3.4 regulates cell migration and invasion through TGF-β-induced epithelial–mesenchymal transition in A549 cells

  • Hun Ju Sim
  • , Mi Ri Kim
  •  & So Yeong Lee

• Article
  19 October 2023 | Open Access

  Adenosine A1 receptors of the medullary solitary tract arbitrate the nicotine counteraction of neuroinflammation and cardiovascular dysfunction in septic rats

  • Amany E. El-Naggar
  • , Mai M. Helmy
  •  & Mahmoud M. El-Mas

• Article
  16 October 2023 | Open Access

  A critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy

  • Alena Randáková
  • , Dominik Nelic
  •  & Jan Jakubík

• Article
  26 September 2023 | Open Access

  Recovery of the histamine H₃ receptor activity lost in yeast cells through error-prone PCR and in vivo selection

  • Ayami Watanabe
  • , Ami Nakajima
  •  & Mitsunori Shiroishi

• Article
  17 March 2023 | Open Access

  Kinin B₁ and B₂ receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors

  • Indiara Brusco
  • , Gabriela Becker
  •  & Sara Marchesan Oliveira

• Article
  20 January 2023 | Open Access

  Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

  • Arundhasa Chandrabalan
  • , Andrew Firth
  •  & Rithwik Ramachandran

• Article
  06 November 2022 | Open Access

  Quantification of receptor binding from response data obtained at different receptor levels: a simple individual sigmoid fitting and a unified SABRE approach

  • Peter Buchwald

• Article
  27 July 2022 | Open Access

  Eicosapentaenoic acid (EPA)-induced inhibitory effects on porcine coronary and cerebral arteries involve inhibition of prostanoid TP receptors

  • Kento Yoshioka
  • , Keisuke Obara
  •  & Yoshio Tanaka

• Article
  15 July 2022 | Open Access

  Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling

  • Sheyda Najafi
  • , Leonard Barasa
  •  & Jeanette C. Perron

• Article
  19 June 2022 | Open Access

  In vitro study on efficacy of PHELA, an African traditional drug against SARS-CoV-2

  • M. G. Matsabisa
  • , K. Alexandre
  •  & H. P. Chabalala

• Article
  10 June 2022 | Open Access

  Investigating the ligand agonism and antagonism at the D_2long receptor by dynamic mass redistribution

  • Lisa Forster
  •  & Steffen Pockes

• Article
  07 March 2022 | Open Access

  Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β₂ adrenergic agonist

  • Artur Wnorowski
  • , Danuta Dudzik
  •  & Irving W. Wainer

• Article
  24 February 2022 | Open Access

  Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

  • Alexander Medvedev
  • , Matt Moeser
  •  & Sergei S. Makarov

• Article
  17 February 2022 | Open Access

  Platelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder

  • Ge Liu
  • , Mizuki Kaneko
  •  & Yoshio Tanaka

• Article
  16 August 2021 | Open Access

  A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins

  • Rodrigo Aguayo-Ortiz
  • , Jeffery Creech
  •  & L. Michel Espinoza-Fonseca

• Article
  08 July 2021 | Open Access

  Identification of V6.51L as a selectivity hotspot in stereoselective A_2B adenosine receptor antagonist recognition

  • Xuesong Wang
  • , Willem Jespers
  •  & Hugo Gutiérrez-de-Terán

• Article
  07 July 2021 | Open Access

  Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2

  • Abanoub A. Gad
  • , Pedram Azimzadeh
  •  & Nariman Balenga

• Article
  10 June 2021 | Open Access

  Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors

  • Hubert J. Sijben
  • , Wieke M. van Oostveen
  •  & Laura H. Heitman

• Article
  19 April 2021 | Open Access

  The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

  • Hamideh Bashiri
  • , Danielle J. Houwing
  •  & Ali-Akbar Salari

• Article
  15 April 2021 | Open Access

  New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D₂ receptor regulation and signaling

  • Anika Mann
  • , Alastair C. Keen
  •  & J. Robert Lane

• Article
  11 March 2021 | Open Access

  Pentagalloyl glucose inhibits TNF‐α‐activated CXCL1/GRO-α expression and induces apoptosis‐related genes in triple-negative breast cancer cells

  • Patricia Mendonca
  • , Sumaih Alghamdi
  •  & Karam F. A. Soliman

• Article
  16 February 2021 | Open Access

  Altered functional properties of the codling moth Orco mutagenized in the intracellular loop-3

  • Yuriy V. Bobkov
  • , William B. Walker III
  •  & Alberto Maria Cattaneo

• Article
  18 January 2021 | Open Access

  Enhancement of parvalbumin interneuron-mediated neurotransmission in the retrosplenial cortex of adolescent mice following third trimester-equivalent ethanol exposure

  • Clark W. Bird
  • , Glenna J. Chavez
  •  & C. Fernando Valenzuela

• Article
  14 January 2021 | Open Access

  A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

  • Hubert J. Sijben
  • , Julie J. E. van den Berg
  •  & Laura H. Heitman

• Article
  11 January 2021 | Open Access

  Development of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons

  • Rebecca Hagan
  • , Elizabeth Rex
  •  & Yi Liu

• Article
  08 January 2021 | Open Access

  A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability

  • Magdalena Nikolaeva-Koleva
  • , Laura Butron
  •  & Antonio Ferrer-Montiel

• Article
  27 November 2020 | Open Access

  Pharmacological characterisation of novel adenosine A₃ receptor antagonists

  • Kerry Barkan
  • , Panagiotis Lagarias
  •  & Graham Ladds

• Article
  23 November 2020 | Open Access

  In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa

  • Ayat Zagzoog
  • , Kawthar A. Mohamed
  •  & Robert B. Laprairie

• Article
  29 October 2020 | Open Access

  Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer

  • Viswas Raja Solomon
  • , Elahe Alizadeh
  •  & Humphrey Fonge

• Article
  15 October 2020 | Open Access

  Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

  • Thor C. Møller
  • , Mie F. Pedersen
  •  & Hans Bräuner-Osborne

• Article
  02 September 2020 | Open Access

  Dopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors

  • Jace Jones-Tabah
  • , Hanan Mohammad
  •  & Terence E. Hébert

• Article
  02 September 2020 | Open Access

  The operational model of allosteric modulation of pharmacological agonism

  • Jan Jakubík
  • , Alena Randáková
  •  & Vladimír Doležal

• Article
  17 August 2020 | Open Access

  Oral Phyto-thymol ameliorates the stress induced IBS symptoms

  • Selvaraj Subramaniyam
  • , Shuyou Yang
  •  & Sanjib Bhattacharyya

• Article
  11 August 2020 | Open Access

  Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H₃ receptor for Prader–Willi Syndrome

  • David Reiner
  • , Ludwig Seifert
  •  & Holger Stark

• Article
  07 August 2020 | Open Access

  A single unified model for fitting simple to complex receptor response data

  • Peter Buchwald

• Article
  06 August 2020 | Open Access

  Levodopa inhibits the development of lens-induced myopia in chicks

  • Kate Thomson
  • , Ian Morgan
  •  & Regan Ashby

• Article
  22 June 2020 | Open Access

  Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA_A receptors

  • Christina Birkedahl Falk-Petersen
  • , Tsonko M. Tsonkov
  •  & Petrine Wellendorph

• Article
  08 June 2020 | Open Access

  Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression

  • James M. Brimson
  • , Kiran K. Akula
  •  & Stephen T. Safrany

• Article
  04 June 2020 | Open Access

  Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors

  • Vanessa Vezzi
  • , Caterina Ambrosio
  •  & Susanna Cotecchia

• Article
  29 May 2020 | Open Access

  Signal profiling of the β₁AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β₁AR and β₂AR

  • Viktoriya Lukasheva
  • , Dominic Devost
  •  & Terence E. Hébert

• Article
  29 May 2020 | Open Access

  Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy

  • Lucia Scarabel
  • , Marica Garziera
  •  & Silvano Geremia

• Article
  19 May 2020 | Open Access

  Drosophila taste neurons as an agonist-screening platform for P2X receptors

  • Leanne Grimes
  • , Julia Griffiths
  •  & Wynand van der Goes van Naters

• Article
  20 February 2020 | Open Access

  A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain

  • Louis Hilfiger
  • , Qian Zhao
  •  & Alexandre Charlet

• Article
  21 January 2020 | Open Access

  Structure-based development of caged dopamine D₂/D₃ receptor antagonists

  • Marie Gienger
  • , Harald Hübner
  •  & Peter Gmeiner

• Article
  17 January 2020 | Open Access

  The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis

  • Kanako Miyano
  • , Moeko Eto
  •  & Yasuhito Uezono

• Article
  31 December 2019 | Open Access

  Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model

  • Masahiro Fuwa
  • , Masaaki Kageyama
  •  & Kei Tashiro

• Article
  17 December 2019 | Open Access

  I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V₂ receptor

  • Leopold Duerrauer
  • , Edin Muratspahić
  •  & Christian W. Gruber

• Article
  13 December 2019 | Open Access

  Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma

  • Nancy S. Younis
  • , Amal M. H. Ghanim
  •  & Sameh Saber