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| Open AccessAutocorrelation analysis of a phenotypic screen reveals hidden drug activity
- Richard A. Dubach
- & J. Matthew Dubach
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Article
| Open AccessOn the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation
- Xixi Wang
- , Yanfei Wang
- & Yalian Sa
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Article
| Open AccessExploration of the photothermal role of curcumin-loaded targeted carbon nanotubes as a potential therapy for melanoma cancer
- Bahareh Kargar
- , Mehdi Fazeli
- & Amin Reza Akbarizadeh
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Article
| Open AccessPreparation and characterization of artemether-loaded niosomes in Leishmania major-induced cutaneous leishmaniasis
- Uranous Niroumand
- , Mohammad Hossein Motazedian
- & Soliman Mohammadi-Samani
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| Open AccessAn eco-friendly and cost-effective HPTLC method for quantification of COVID-19 antiviral drug and co-administered medications in spiked human plasma
- Ekram A. Ghozzy
- , Nahed M. El-Enany
- & Samah Abo El Abass
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| Open AccessPorphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents
- Debdulal Sharma
- , Aradhana Singh
- & Devashish Sengupta
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Article
| Open AccessInjectable hydrogel with doxorubicin-loaded ZIF-8 nanoparticles for tumor postoperative treatments and wound repair
- Qiang Zhang
- , Yu Zhang
- & Zhen-Fa Zhang
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Article
| Open AccessCheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2
- Jobin Thomas
- , Anupam Ghosh
- & Jitendra Satija
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Article
| Open AccessPreclinical evaluation of novel synthesised nanoparticles based on tyrosine poly(ester amide) for improved targeted pulmonary delivery
- Eman Zmaily Dahmash
- , Nour Radwan Achkar
- & Hamad Alyami
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Article
| Open AccessEnhancing effect of natural adjuvant, panduratin A, on antibacterial activity of colistin against multidrug-resistant Acinetobacter baumannii
- Nalumon Thadtapong
- , Soraya Chaturongakul
- & Sunhapas Soodvilai
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Article
| Open AccessIdentification of PANoptosis-related biomarkers and analysis of prognostic values in head and neck squamous cell carcinoma
- Ping Yang
- , Guangzhao Huang
- & Qian Li
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Article
| Open AccessSGLT2i impact on HCC incidence in patients with fatty liver disease and diabetes: a nation-wide cohort study in South Korea
- Hyo Jung Cho
- , Eunyoung Lee
- & Jae Youn Cheong
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Article
| Open AccessLigand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches
- Md. Rezaul Islam
- , Md. Shafiqul Islam Sovon
- & Gezahign Fentahun Wondmie
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Article
| Open AccessSphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies
- Shinsuke Nakamura
- , Rie Yamamoto
- & Hideaki Hara
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Article
| Open AccessGenetic polymorphisms and clinical parameters associated with renal toxicity in Thai hematologic malignancy patients receiving high dose methotrexate
- Palada Pitakkitnukun
- , Thanakit Pongpitakmetha
- & Chantana Polprasert
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Article
| Open AccessQuality control in SARS-CoV-2 RBD-Fc vaccine production using LC–MS to confirm strain selection and detect contaminations from other strains
- Pipob Suwanchaikasem
- , Kaewta Rattanapisit
- & Waranyoo Phoolcharoen
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Article
| Open AccessAnti-inflammatory and anti-diabetic properties of indanone derivative isolated from Fernandoa adenophylla in vitro and in silico studies
- Abdur Rauf
- , Umer Rashid
- & Dorota Formanowicz
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Article
| Open AccessAgonist-selective activation of individual G-proteins by muscarinic receptors
- Dominik Nelic
- , Nikolai Chetverikov
- & Alena Janoušková-Randáková
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Article
| Open AccessApigenin and its combination with Vorinostat induces apoptotic-mediated cell death in TNBC by modulating the epigenetic and apoptotic regulators and related miRNAs
- Snehal Nimal
- , Navanath Kumbhar
- & Rajesh N. Gacche
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Article
| Open AccessSynthesis and molecular docking studies of new aryl imeglimin derivatives as a potent antidiabetic agent in a diabetic zebrafish model
- Aylin Khodakhah
- , Hassan Mohammadi
- & Massoud Amanlou
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Article
| Open AccessPredicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints
- Zaid Anis Sherwani
- , Syeda Sumayya Tariq
- & Zaheer Ul-Haq
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Article
| Open AccessExploring a repurposed candidate with dual hIDO1/hTDO2 inhibitory potential for anticancer efficacy identified through pharmacophore-based virtual screening and in vitro evaluation
- Nourhan M. Aboomar
- , Omar Essam
- & Reem K. Arafa
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| Open AccessHBCVTr: an end-to-end transformer with a deep neural network hybrid model for anti-HBV and HCV activity predictor from SMILES
- Ittipat Meewan
- , Jiraporn Panmanee
- & Pichaya Lertvilai
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Article
| Open AccessDiscovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation
- En Gao
- , Ya Wang
- & Shouhu Li
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Article
| Open AccessDesign of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity
- Hamza Assaggaf
- , Mohamed Jeddi
- & Naoufal El Hachlafi
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Article
| Open AccessHexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
- Oleh Durydivka
- , Petr Palivec
- & Martin Kuchar
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Article
| Open AccessTumor growth-arrest effect of tetrahydroquinazoline-derivative human topoisomerase II-alpha inhibitor in HPV-negative head and neck squamous cell carcinoma
- Patrizia Sarogni
- , Nicoletta Brindani
- & Valerio Voliani
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Article
| Open AccessEpigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
- Zachary C. Rosenthal
- , Daniel M. Fass
- & Stephen J. Haggarty
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Article
| Open AccessFactors associated with hematological adverse reactions of drugs authorized via the centralized procedure
- Ivana Stević
- , Slobodan M. Janković
- & Dragana Lakić
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Article
| Open AccessSMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia
- Hannah Åbacka
- , Samuele Masoni
- & Karin Lindkvist-Petersson
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Article
| Open AccessSynthesis, biofilm formation inhibitory, and inflammation inhibitory activities of new coumarin derivatives
- Ghada E. Ahmed
- , Zeinab A. Elshahid
- & Anhar Abdel-Aziem
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Article
| Open AccessProtein characteristics substantially influence the propensity of activity cliffs among kinase inhibitors
- Safa Daoud
- & Mutasem Taha
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Article
| Open AccessL-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats
- James N. Bates
- , Santhosh M. Baby
- & Stephen J. Lewis
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Article
| Open AccessNarazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models
- Tao Yang
- , Hang Ke
- & Qi-Xiang Li
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Article
| Open AccessC16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer
- Yu Hashimoto
- , Yoshio Tokumoto
- & Yoichi Hiasa
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Article
| Open AccessStatine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro)
- Pedro Henrique R. de A. Azevedo
- , Priscila G. Camargo
- & Estela Maris F. Muri
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Article
| Open AccessAffinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
- Mikael Jumppanen
- , Sini M. Kinnunen
- & Jari Yli-Kauhaluoma
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Article
| Open AccessDisruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC
- Sean F. Cooke
- , Thomas A. Wright
- & Connor M. Blair
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| Open AccessDissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS) for oral delivery
- Boontida Morakul
- , Veerawat Teeranachaideekul
- & Varaporn Buraphacheep Junyaprasert
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Article
| Open AccessIn silico exploration of phenolics as modulators of penicillin binding protein (PBP) 2× of Streptococcus pneumoniae
- Jamiu Olaseni Aribisala
- , Nosipho Wendy S’thebe
- & Saheed Sabiu
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Article
| Open AccessSirolimus-coated Eustachian tube balloon dilatation for treating Eustachian tube dysfunction in a rat model
- Jeon Min Kang
- , Song Hee Kim
- & Jung-Hoon Park
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Article
| Open AccessMolecular modelling studies and in vitro enzymatic assays identified A 4-(nitrobenzyl)guanidine derivative as inhibitor of SARS-CoV-2 Mpro
- Kaio Maciel de Santiago-Silva
- , Priscila Goes Camargo
- & Marcelle de Lima Ferreira Bispo
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Article
| Open AccessDevelopment of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
- Yasuhiro Nakano
- , Eiko Saijou
- & Taketomo Kido
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Article
| Open AccessMolecular identification of Proteus mirabilis, Vibrio species leading to CRISPR-Cas9 modification of tcpA and UreC genes causing cholera and UTI
- Muhammad Naveed
- , Fatima Tahir
- & Abdullah F. Alasmari
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Article
| Open AccessDesign, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents
- Payal Kamboj
- , Anjali
- & Mohd. Amir
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Article
| Open AccessUsing Mendelian randomization provides genetic insights into potential targets for sepsis treatment
- Rui Xia
- , Meng Sun
- & Jianhua Li
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Article
| Open AccessAnticancer, antioxidant, and antibacterial activity of chemically fingerprinted extract from Cyclamen persicum Mill.
- Fuad Al-Rimawi
- , Mahmoud Khalid
- & Mohammed Bourhia
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Article
| Open AccessTranslational research of boron neutron capture therapy for spinal cord gliomas using rat model
- Ryo Kayama
- , Kohei Tsujino
- & Masahiko Wanibuchi
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Article
| Open AccessDP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
- , Michaela Ulrich
- & Moritz Bünemann