Pharmacokinetics articles within Scientific Reports

Featured

• Article
  22 May 2024 | Open Access

  Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

  • Chenyan Zhao
  • , Anders N. Kristoffersson
  •  & Lena E. Friberg

• Article
  10 May 2024 | Open Access

  In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

  • Sean N. Avedissian
  • , Johid R. Malik
  •  & Courtney V. Fletcher

• Article
  15 March 2024 | Open Access

  Development of extended pharmacokinetic models for propofol based on measured blood and brain concentrations

  • Masayoshi Kawata
  • , Atsushi Yonezawa
  •  & Yoshiki Arakawa

• Article
  29 January 2024 | Open Access

  In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

  • Shaimaa E. Diab
  • , Nourhan A. Tayea
  •  & Zakia A. Olama

• Article
  29 November 2023 | Open Access

  1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors

  • Maurício T. Tavares
  • , Arne Krüger
  •  & Roberto Parise-Filho

• Article
  28 September 2023 | Open Access

  Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19

  • Rob C. van Wijk
  • , Laurynas Mockeliunas
  •  & Ulrika S. H. Simonsson

• Article
  25 September 2023 | Open Access

  Physiologically-based pharmacokinetic modeling for optimal dosage prediction of olaparib when co-administered with CYP3A4 modulators and in patients with hepatic/renal impairment

  • Dongmei Gao
  • , Guopeng Wang
  •  & Jiawei Ren

• Article
  11 September 2023 | Open Access

  Adapting physiologically-based pharmacokinetic models for machine learning applications

  • Sohaib Habiballah
  •  & Brad Reisfeld

• Article
  22 July 2023 | Open Access

  Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus)

  • Niora J. Fabian
  • , Anthony J. Mannion
  •  & Jennifer L. Haupt

• Article
  11 July 2023 | Open Access

  Forensic toxicokinetics of difenidol hydrochloride in vivo verified by practical lethal cases

  • Weifen Niu
  • , Tongxi Ren
  •  & Keming Yun

• Article
  08 July 2023 | Open Access

  Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides

  • L. Reveret
  • , M. Leclerc
  •  & F. Calon

• Article
  29 June 2023 | Open Access

  Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics

  • Justin Frosina
  • , Michael McEwan
  •  & George Hardie

• Article
  13 March 2023 | Open Access

  Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model

  • Evgenii Kim
  • , Hyun-Chul Kim
  •  & Wonhye Lee

• Article
  15 February 2023 | Open Access

  Application of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease

  • Sundus Khalid
  • , Muhammad Fawad Rasool
  •  & Faleh Alqahtani

• Article
  13 February 2023 | Open Access

  A validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract

  • Phanit Songvut
  • , Nanthanit Pholphana
  •  & Jutamaad Satayavivad

• Article
  19 August 2022 | Open Access

  Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

  • Stéphanie Pochet
  • , Anne-Sophie Lechon
  •  & Florence Souard

• Article
  28 April 2022 | Open Access

  A randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products

  • David Azzopardi
  • , James Ebajemito
  •  & James Murphy

• Article
  21 April 2022 | Open Access

  In vivo dose–response analysis to acetylcholine: pharmacodynamic assessment by polarized reflectance spectroscopy

  • Joakim Henricson
  • , Folke Sjöberg
  •  & Daniel Wilhelms

• Article
  15 April 2022 | Open Access

  ⁸⁹Zr-PET imaging to predict tumor uptake of ¹⁷⁷Lu-NNV003 anti-CD37 radioimmunotherapy in mouse models of B cell lymphoma

  • Danique Giesen
  • , Marjolijn N. Lub-de Hooge
  •  & Martin Pool

• Article
  22 March 2022 | Open Access

  In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody

  • Chisato Kaneko
  • , Haruka Tsutsui
  •  & Masaru Ishii

• Article
  28 February 2022 | Open Access

  Optimization of supercritical-CO₂ extraction and pharmacokinetics in SD rats of alkaloids form Sophora moorcroftiana seed

  • Chunhui Hu
  • , Xuehui Gan
  •  & Fabin Zhang

• Article
  02 February 2022 | Open Access

  Citrate pharmacokinetics in critically ill liver failure patients receiving CRRT

  • Peerapat Thanapongsatorn
  • , Weerachai Chaijamorn
  •  & Nattachai Srisawat

• Article
  27 January 2022 | Open Access

  Bioinformatics approaches identified dasatinib and bortezomib inhibit the activity of MCM7 protein as a potential treatment against human cancer

  • Abdus Samad
  • , Md. Amdadul Huq
  •  & Md. Shahedur Rahman

• Article
  18 November 2021 | Open Access

  Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

  • Kumiko Taira
  • , Tomonori Kawakami
  •  & Makiko Komori

• Article
  05 October 2021 | Open Access

  Extract from Dioscorea bulbifera L. rhizomes aggravate pirarubicin-induced cardiotoxicity by inhibiting the expression of P-glycoprotein and multidrug resistance-associated protein 2 in the mouse liver

  • Li-rui Sun
  • , Qiu-shi Guo
  •  & Min Li

• Article
  05 October 2021 | Open Access

  Population pharmacokinetic model of cefazolin in total hip arthroplasty

  • J. Lanoiselée
  • , R. Chaux
  •  & E. Ollier

• Article
  16 September 2021 | Open Access

  Azithromycin concentrations during long-term regimen, a pilot study in patients with MALT lymphoma

  • Raphael Scheibenpflug
  • , Markus Obermüller
  •  & Heimo Lagler

• Article
  20 August 2021 | Open Access

  Excessive unbound cefazolin concentrations in critically ill patients receiving veno-arterial extracorporeal membrane oxygenation (vaECMO): an observational study

  • Hendrik Booke
  • , Otto R. Frey
  •  & Elisabeth H. Adam

• Article
  04 August 2021 | Open Access

  Acetylation turns leucine into a drug by membrane transporter switching

  • Grant C. Churchill
  • , Michael Strupp
  •  & Antony Galione

• Article
  22 July 2021 | Open Access

  Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations

  • Lyndsey L. Anderson
  • , Maia G. Etchart
  •  & Jonathon C. Arnold

• Article
  15 June 2021 | Open Access

  Pharmacological and clinical evaluation of deferasirox formulations for treatment tailoring

  • Andrea Piolatto
  • , Paola Berchialla
  •  & Filomena Longo

• Article
  25 May 2021 | Open Access

  Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis

  • Patrick Vizeli
  • , Isabelle Straumann
  •  & Matthias E. Liechti

• Article
  22 April 2021 | Open Access

  A novel method for the storage and transport of biological samples of therapeutic proteins prior to the detection of analytes using ELISA

  • Lei Wang
  • , Lixiong Liu
  •  & Zeneng Cheng

• Article
  21 April 2021 | Open Access

  Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases

  • Muhammad F. Rasool
  • , Shazia Ali
  •  & Faleh Alqahtani

• Article
  25 March 2021 | Open Access

  Pharmacokinetics and metabolomics investigation of an orally modified formula of standardized Centella asiatica extract in healthy volunteers

  • Phanit Songvut
  • , Pajaree Chariyavilaskul
  •  & Rossarin Tansawat

• Article
  11 March 2021 | Open Access

  Enteric reabsorption processes and their impact on drug pharmacokinetics

  • Manuel Ibarra
  • , Iñaki F. Trocóniz
  •  & Pietro Fagiolino

• Article
  01 March 2021 | Open Access

  A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses

  • Pim de Haan
  • , Milou J. C. Santbergen
  •  & Elisabeth Verpoorte

• Article
  28 January 2021 | Open Access

  Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody

  • Takahiro Morito
  • , Ryuichi Harada
  •  & Kazuhiko Yanai

• Article
  28 January 2021 | Open Access

  Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

  • Dong Liang
  • , Jing Ma
  •  & Bo Wei

• Article
  12 January 2021 | Open Access

  Evaluation for pharmacokinetic exposure of cytotoxic anticancer drugs in elderly patients receiving (R-)CHOP therapy

  • Junichi Nakagawa
  • , Takenori Takahata
  •  & Takenori Niioka

• Article
  11 January 2021 | Open Access

  Early impact of donor CYP3A5 genotype and Graft-to-Recipient Weight Ratio on tacrolimus pharmacokinetics in pediatric liver transplant patients

  • Michele Pinon
  • , Amedeo De Nicolò
  •  & Pier Luigi Calvo

• Article
  24 November 2020 | Open Access

  A randomised controlled single-centre open-label pharmacokinetic study to examine various approaches of nicotine delivery using electronic cigarettes

  • James K. Ebajemito
  • , Michael McEwan
  •  & Christopher J. Proctor

• Article
  02 November 2020 | Open Access

  Pharmacokinetic–pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats

  • Makoto Miyazaki
  • , Mariko Hayata
  •  & Junya Nagai

• Article
  22 October 2020 | Open Access

  Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties

  • Brice Martin
  • , Johanne Seguin
  •  & Yohann Corvis

• Article
  20 August 2020 | Open Access

  A double-Flp-in method for stable overexpression of two genes

  • Ole Jensen
  • , Salim Ansari
  •  & Jürgen Brockmöller

• Article
  27 July 2020 | Open Access

  Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin

  • Chih-hsuan Hsin
  • , Marc S. Stoffel
  •  & Max Taubert

• Article
  25 June 2020 | Open Access

  The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics

  • Justyna Schubert
  • , Tanja Khosrawipour
  •  & Veria Khosrawipour

• Article
  29 May 2020 | Open Access

  Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy

  • Lucia Scarabel
  • , Marica Garziera
  •  & Silvano Geremia

• Article
  24 March 2020 | Open Access

  Time-resolved fluorescence microscopy with phasor analysis for visualizing multicomponent topical drug distribution within human skin

  • Sinyoung Jeong
  • , Daniel A. Greenfield
  •  & Conor L. Evans

• Article
  12 March 2020 | Open Access

  Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice

  • Michael A. Malfatti
  • , Edward A. Kuhn
  •  & Gabriela G. Loots