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| Open AccessA critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy
- Alena Randáková
- , Dominik Nelic
- & Jan Jakubík
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| Open AccessThe suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats
- Sherien A. Abdelhady
- , Mennatallah A. Ali
- & Mahmoud M. El-Mas
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| Open AccessPsilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences
- Nathalie M. Rieser
- , Ladina P. Gubser
- & Katrin H. Preller
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| Open AccessNetwork pharmacology and experimental verification of the potential mechanism of Er-Xian decoction in aplastic anemia
- Mei Ye
- , Guangxian Liu
- & Zeli Gao
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| Open AccessMercaptonicotinic acid activated thiolated chitosan (MNA-TG-chitosan) to enable peptide oral delivery by opening cell tight junctions and enhancing transepithelial transport
- Anubhav Pratap-Singh
- , Yigong Guo
- & Anika Singh
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| Open AccessA memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration
- Lihong Cheng
- , Mitsuru Tanaka
- & Toshiro Matsui
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| Open AccessThe anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis
- Erik Márk Orján
- , Eszter Sára Kormányos
- & Lóránd Kiss
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| Open AccessReproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19
- Rob C. van Wijk
- , Laurynas Mockeliunas
- & Ulrika S. H. Simonsson
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| Open AccessRecovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection
- Ayami Watanabe
- , Ami Nakajima
- & Mitsunori Shiroishi
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| Open AccessPhysiologically-based pharmacokinetic modeling for optimal dosage prediction of olaparib when co-administered with CYP3A4 modulators and in patients with hepatic/renal impairment
- Dongmei Gao
- , Guopeng Wang
- & Jiawei Ren
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| Open AccessPropolis-loaded nanostructured lipid carriers halt breast cancer progression through miRNA-223 related pathways: an in-vitro/in-vivo experiment
- Sara A. Shaker
- , Shadi M. Alshufta
- & Rasha A. El-Tahan
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| Open AccessRevealing mechanism of Methazolamide for treatment of ankylosing spondylitis based on network pharmacology and GSEA
- Tao Sun
- , Manzhi Wang
- & Xinfeng Yan
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| Open AccessAdapting physiologically-based pharmacokinetic models for machine learning applications
- Sohaib Habiballah
- & Brad Reisfeld
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| Open AccessAsarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ
- Qian Zeng
- , Ting-ting Zhou
- & Si-yuan Tang
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| Open AccessExploring the role and mechanism of Astragalus membranaceus and radix paeoniae rubra in idiopathic pulmonary fibrosis through network pharmacology and experimental validation
- Huanyu Jiang
- , Rui Zhou
- & Quanyu Du
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| Open AccessInteractions of the male contraceptive target EPPIN with semenogelin-1 and small organic ligands
- Antoniel A. S. Gomes
- , Natália C. M. Santos
- & Erick J. R. Silva
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| Open AccessA cell-based assay for rapid assessment of ACE2 catalytic function
- Warren M. Meyers
- , Ryan J. Hong
- & Kurt Haas
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| Open AccessExploring the mechanism of luteolin by regulating microglia polarization based on network pharmacology and in vitro experiments
- Tianyue Wang
- , Yuanjun Yin
- & Lin Li
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| Open AccessCo-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences
- Richard J. Zeifman
- , Hannes Kettner
- & Robin L. Carhart-Harris
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| Open AccessCuticular property affects the insecticidal synergy of major constituents in thyme oil against houseflies, Musca domestica
- Junho Yoon
- & Jun-Hyung Tak
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| Open AccessActive ingredients Isorhamnetin of Croci Srigma inhibit stomach adenocarcinomas progression by MAPK/mTOR signaling pathway
- Xue-feng Shi
- , Qi Yu
- & Ting Cai
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| Open AccessExploring the association between selective serotonin reuptake inhibitors and rhabdomyolysis risk based on the FDA pharmacovigilance database
- Yan Wang
- , Yajing Lin
- & Dongbo Jiang
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| Open AccessSericin coated thin polymeric films reduce keratinocyte proliferation via the mTOR pathway and epidermal inflammation through IL17 signaling in psoriasis rat model
- Pornanong Aramwit
- , Kamonpan Fongsodsri
- & Sumate Ampawong
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| Open AccessMolecular basis of GDF15 induction and suppression by drugs in cardiomyocytes and cancer cells toward precision medicine
- Lisa-Maria Winter
- , Diana Reinhardt
- & Seong-Wook Yun
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| Open AccessDuality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography
- Alexey Y. Sokolov
- , Maxim A. Volynsky
- & Alexei A. Kamshilin
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| Open AccessPregnancy outcomes after vaginal probiotic supplementation before frozen embryo transfer: a randomized controlled study
- Isarin Thanaboonyawat
- , Sootthinan Pothisan
- & Pitak Laokirkkiat
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| Open AccessEvaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus)
- Niora J. Fabian
- , Anthony J. Mannion
- & Jennifer L. Haupt
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| Open AccessThe effect of intravenous granisetron on prophylactic ephedrine for preventing hypotension after general anaesthesia induction in elderly patients: a randomized controlled trial
- Youfa Zhou
- , Cencen Wang
- & Gang Chen
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| Open AccessSacubitril/valsartan mitigates cardiac remodeling, systolic dysfunction, and preserves mitochondrial quality in a rat model of mitral regurgitation
- Lalida Tantisuwat
- , Nakkawee Saengklub
- & Anusak Kijtawornrat
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| Open AccessForensic toxicokinetics of difenidol hydrochloride in vivo verified by practical lethal cases
- Weifen Niu
- , Tongxi Ren
- & Keming Yun
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| Open AccessPharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
- L. Reveret
- , M. Leclerc
- & F. Calon
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| Open AccessARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo
- Teiko Komori Nomura
- , Satoshi Endo
- & Ryo Honda
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| Open AccessAssessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics
- Justin Frosina
- , Michael McEwan
- & George Hardie
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| Open AccessMeasuring the diversity gap of cannabis clinical trial participants compared to people who report using cannabis
- Heather Barkholtz
- & Maia Bates
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| Open AccessSitagliptin ameliorates busulfan-induced pulmonary and testicular injury in rats through antioxidant, anti-inflammatory, antifibrotic, and antiapoptotic effects
- Eman A. Ali
- , Sara G. Tayel
- & Mona A. Abbas
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| Open AccessUse of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma
- Minhua Hu
- , Hongsong Yan
- & Hang Dong
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| Open AccessReal-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry
- Nadine Colé
- , Janina Thoele
- & Richard H. Foxton
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| Open AccessEvaluation of rosuvastatin-induced QT prolongation risk using real-world data, in vitro cardiomyocyte studies, and mortality assessment
- Yeryung Koo
- , Sung-Ae Hyun
- & Dukyong Yoon
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| Open AccessCannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region
- Mark Tripson
- , Karen Litwa
- & Ken Soderstrom
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| Open AccessMachine learning analysis predicts a person’s sex based on mechanical but not thermal pain thresholds
- Jörn Lötsch
- , Benjamin Mayer
- & Dario Kringel
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| Open AccessN,N-dimethylacetamide targets neuroinflammation in Alzheimer’s disease in in-vitro and ex-vivo models
- Zeng-Hui Wei
- , Jagadish Koya
- & Sandra E. Reznik
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| Open AccessThe efficacy of bimatoprost ophthalmic solution combined with NB-UVB phototherapy in non-segmental and segmental vitiligo: a single-blind randomized controlled study
- Narumol Silpa-archa
- , Surachanee Likittanasombat
- & Chanisada Wongpraparut
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| Open AccessIn vitro PCR verification that lysozyme inhibits nucleic acid replication and transcription
- Lu Liu
- , Xu Jia
- & Qian Zheng
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| Open AccessCZK, a novel alkaloid derivative from Clausena lansium, alleviates ischemic stroke injury through Nrf2-mediated antioxidant effects
- Haodong Chen
- , Yangbo Liu
- & Naihong Chen
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| Open AccessAsperuloside attenuates cadmium-induced toxicity by inhibiting oxidative stress, inflammation, fibrosis and apoptosis in rats
- Zhiyang Kong
- , Chunhong Liu
- & Opeyemi Joshua Olatunji
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| Open AccessChannel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites
- Marina Sherif Fam
- , Christine Adel Sedky
- & Ulrike Breitinger
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| Open AccessExploring the components and mechanisms of Shen-qi-wang-mo granule in the treatment of retinal vein occlusion by UPLC-Triple TOF MS/MS and network pharmacology
- Yi Zhao
- , Cui Ma
- & Zhenghua Wu
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| Open AccessAcetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways
- Emad H. M. Hassanein
- , Adel G. Bakr
- & Fares E. M. Ali
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| Open AccessRepertoire of P-glycoprotein drug transporters in the zoonotic nematode Toxocara canis
- Jeba R. J. Jesudoss Chelladurai
- , Katy A. Martin
- & Matthew T. Brewer