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| Open AccessCOPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation
- Frédéric Anglès
- , Vijay Gupta
- & William E. Balch
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| Open AccessCORVET-specific subunit levels determine the balance between HOPS/CORVET endosomal tethering complexes
- Ármin Sőth
- , Márton Molnár
- & Gábor Juhász
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Article
| Open AccessOn the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation
- Xixi Wang
- , Yanfei Wang
- & Yalian Sa
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Editorial
| Open AccessMitochondrial dynamics: updates and perspectives
Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.
- Kezhong Zhang
- & Ježek Petr
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Article
| Open AccessA high efficiency precision genome editing method with CRISPR in iPSCs
- Avinash Singh
- , G. Dalton Smedley
- & Shauna H. Yuan
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Article
| Open AccessA minimal Fanconi Anemia complex in early diverging fungi
- Drishtee Barua
- , Magdalena Płecha
- & Anna Muszewska
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Article
| Open AccessPolyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
- Nina Kunová
- , Gabriela Ondrovičová
- & Vladimír Pevala
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Article
| Open AccessSaturated fatty acids inhibit unsaturated fatty acid induced glucose uptake involving GLUT10 and aerobic glycolysis in bovine granulosa cells
- Xuelian Tao
- , Maryam Rahimi
- & Vijay Simha Baddela
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Article
| Open AccessComparing the efficacy of concomitant treatment of resistance exercise and creatine monohydrate versus multiple individual therapies in age related sarcopenia
- Eman I. Elgizawy
- , Ghada S. Amer
- & Anwar M. Shaban
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Article
| Open AccessMechanical stimulation of induced pluripotent stem derived cardiac fibroblasts
- Fjodor T. Bekedam
- , Rowan Smal
- & Aida Llucià-Valldeperas
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Article
| Open AccessGross morphology and adhesion-associated physical properties of Drosophila larval salivary gland glue secretion
- Milan Beňo
- , Denisa Beňová-Liszeková
- & Robert Farkaš
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Article
| Open AccessGenetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways
- Aleah Goldberg
- , Patrick O’Connor
- & Antonio Gonzalez
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Article
| Open AccessPotential probiotic Lactobacillus delbrueckii subsp. lactis KUMS-Y33 suppresses adipogenesis and promotes osteogenesis in human adipose-derived mesenchymal stem cell
- Farjam Goudarzi
- , Amir Kiani
- & Babak Haghshenas
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Article
| Open AccessAnti-inflammatory and anti-diabetic properties of indanone derivative isolated from Fernandoa adenophylla in vitro and in silico studies
- Abdur Rauf
- , Umer Rashid
- & Dorota Formanowicz
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Article
| Open AccessSuperovulation with an anti-inhibin monoclonal antibody improves the reproductive performance of rat strains by increasing the pregnancy rate and the litter size
- Keiji Mochida
- , Kohtaro Morita
- & Atsuo Ogura
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Article
| Open AccessIntegrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression
- Allice Santos Cruz Veras
- , Victor Rogério Garcia Batista
- & Giovana Rampazzo Teixeira
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Article
| Open AccessAgonist-selective activation of individual G-proteins by muscarinic receptors
- Dominik Nelic
- , Nikolai Chetverikov
- & Alena Janoušková-Randáková
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Article
| Open AccessGingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis
- Cláudio Rodrigues Rezende Costa
- , Rym Chalgoumi
- & Ana Carolina Acevedo
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Article
| Open AccessComparative analysis of SEC61A1 mutant R236C in two patient-derived cellular platforms
- Matthias Weiand
- , Vanessa Sandfort
- & Andree Zibert
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Article
| Open AccessReplication protein-A, RPA, plays a pivotal role in the maintenance of recombination checkpoint in yeast meiosis
- Arivarasan Sampathkumar
- , Chen Zhong
- & Akira Shinohara
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Article
| Open AccessThe effect of continuous long-term illumination with visible light in different spectral ranges on mammalian cells
- Sophie Dani
- , Kathleen Schütz
- & Anja Lode
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Article
| Open AccessDCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/β-catenin signaling
- Qing-Qing Liu
- , Jing Chen
- & Cui-Hua Lu
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Article
| Open AccessA high-cholesterol diet promotes the intravasation of breast tumor cells through an LDL–LDLR axis
- Ana Magalhães
- , Vanessa Cesário
- & Sérgio Dias
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Article
| Open AccessANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder
- Matthias Przyklenk
- , Shreya Karmacharya
- & Alvise Schiavinato
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Article
| Open AccessIntelligent berberine-loaded erythrocytes attenuated inflammatory cytokine productions in macrophages
- Zahra Sadat Aghili
- , Mauro Magnani
- & Mehdi Banitalebi Dehkordi
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Article
| Open AccessSingle-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster
- Ting Zhou
- , Jing Pan
- & Yaling Han
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Article
| Open AccessDexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation
- Ruijuan Du
- , Nan Xiao
- & Hua Bian
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Article
| Open AccessA novel multidrug-resistant cell line from a Chinese patient with pancreatic ductal adenocarcinoma
- Huan Tang
- , Xin Miao
- & Wence Zhou
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Article
| Open AccessHexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
- Oleh Durydivka
- , Petr Palivec
- & Martin Kuchar
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Article
| Open AccessSignificance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19
- Blanka Wolszczak-Biedrzycka
- , Justyna Dorf
- & Mateusz Maciejczyk
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Article
| Open AccessMechanism study of tyrosine phosphatase shp-1 in inhibiting hepatocellular carcinoma progression by regulating the SHP2/GM-CSF pathway in TAMs
- Qiang Wei
- , ShuBin Luo
- & Gang He
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Article
| Open AccessA high-precision wound healing assay based on photosensitized culture substrates
- Saphia Azzam
- , Lea Tomasova
- & Joachim Wegener
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Article
| Open AccessAlfalfa xeno-miR159a regulates bovine mammary epithelial cell proliferation and milk protein synthesis by targeting PTPRF
- Hongjuan Duan
- , Shaojin Li
- & Xiaoyan Cai
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Article
| Open AccessEnhanced potent immunosuppression of intracellular adipose tissue-derived stem cell extract by priming with three-dimensional spheroid formation
- Witchayapon Kamprom
- , Rattanawan Tangporncharoen
- & Aungkura Supokawej
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Article
| Open AccessTMAO enhances TNF-α mediated fibrosis and release of inflammatory mediators from renal fibroblasts
- Kapetanaki Stefania
- , Kumawat Kumar Ashok
- & Demirel Isak
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Article
| Open AccessExperience-dependent glial pruning of synaptic glomeruli during the critical period
- Nichalas Nelson
- , Dominic J. Vita
- & Kendal Broadie
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Article
| Open AccessClassification and counting of cells in brightfield microscopy images: an application of convolutional neural networks
- E. K. G. D. Ferreira
- & G. F. Silveira
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Article
| Open AccessDe novo reconstruction of a functional in vivo-like equine endometrium using collagen-based tissue engineering
- Sawita Santiviparat
- , Theerawat Swangchan-Uthai
- & Theerawat Tharasanit
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Article
| Open AccessDiverse effects of a Cyperus rotundus extract on glucose uptake in myotubes and adipocytes and its suppression on adipocyte maturation
- Vipawee Pichetkun
- , Hnin Ei Ei Khine
- & Chaisak Chansriniyom
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Article
| Open AccessConstruction and verification of a histone deacetylases-related prognostic signature model for colon cancer
- Lei Hao
- , Weiqi Lu
- & Peizong Wang
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Article
| Open AccessDisruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC
- Sean F. Cooke
- , Thomas A. Wright
- & Connor M. Blair
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Article
| Open AccessDiscrimination of distinct chicken M cell subsets based on CSF1R expression
- Safieh Zeinali
- , Kate Sutton
- & Lonneke Vervelde
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Article
| Open AccessEPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary
- Jacinta H. Martin
- , Ilana R. Bernstein
- & Tessa Lord
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Article
| Open AccessUncovering the impact of UV radiation on mitochondria in dermal cells: a STED nanoscopy study
- Hyung Jun Kim
- , Seon-Pil Jin
- & Jin Ho Chung
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Article
| Open AccessOPN silencing reduces hypoxic pulmonary hypertension via PI3K-AKT-induced protective autophagy
- Rui Zhou
- , Ran Li
- & Shenglan Wang
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Article
| Open AccessGenetic interference with HvNotch provides new insights into the role of the Notch-signalling pathway for developmental pattern formation in Hydra
- Qin Pan
- , Moritz Mercker
- & Angelika Böttger
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Article
| Open AccessEffect of a single immersion in cold water below 4 °C on haemorheological properties of blood in healthy men
- Aneta Teległów
- , Hatice Genç
- & Iwona Cicha
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Article
| Open AccessPhosphoglycerate mutase 5 exacerbates liver ischemia–reperfusion injury by activating mitochondrial fission
- Hongwei Tang
- , Qiwen Yu
- & Xiaoyi Shi
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Article
| Open AccessPossible involvement of zinc transporter ZIP13 in myogenic differentiation
- Masaki Shoji
- , Takuto Ohashi
- & Takashi Kuzuhara
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- Membrane trafficking
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