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| Open AccessThe local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics
- Nicoletta Braidotti
- , Giorgia Demontis
- & Dan Cojoc
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| Open AccessGross morphology and adhesion-associated physical properties of Drosophila larval salivary gland glue secretion
- Milan Beňo
- , Denisa Beňová-Liszeková
- & Robert Farkaš
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| Open AccessGingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis
- Cláudio Rodrigues Rezende Costa
- , Rym Chalgoumi
- & Ana Carolina Acevedo
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| Open AccessEPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary
- Jacinta H. Martin
- , Ilana R. Bernstein
- & Tessa Lord
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| Open AccessMitochondrial Ca2+ signaling is a hallmark of specific adipose tissue-cancer crosstalk
- Agnese De Mario
- , Elisabetta Trevellin
- & Cristina Mammucari
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| Open AccessThe autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
- Patrick J. Ryan
- , Selina Uranga
- & James D. Fluckey
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| Open AccessCharacterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates
- Maiju K. Rinne
- , Lauri Urvas
- & Henri Xhaard
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| Open AccessThe cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts
- Jiunn-Min Shieh
- , Yih-Jeng Tsai
- & Wen-Bin Wu
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| Open AccessPDGFRA K385 mutants in myxoid glioneuronal tumors promote receptor dimerization and oncogenic signaling
- Laurence de Villenfagne
- , Ariane Sablon
- & Jean-Baptiste Demoulin
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| Open AccessActivated fibroblasts modify keratinocyte stem niche through TET1 and IL-6 to promote their rapid transformation in a mouse model of prenatal arsenic exposure
- Anchal Chauhan
- , Siddhartha Gangopadhyay
- & Vikas Srivastava
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| Open AccessMechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epithelium
- Kärki Tytti
- , Koskimäki Sanna
- & Tojkander Sari
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| Open AccessHuman dental pulp stem cells derived extracellular matrix promotes mineralization via Hippo and Wnt pathways
- Chatvadee Kornsuthisopon
- , Nunthawan Nowwarote
- & Thanaphum Osathanon
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| Open AccessNoggin promotes osteogenesis in human adipose-derived mesenchymal stem cells via FGFR2/Src/Akt and ERK signaling pathway
- Karolina Truchan
- & Anna Maria Osyczka
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| Open AccessUltra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics
- Delia I. Fernández
- , Sara Troitiño
- & Johan W. M. Heemskerk
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| Open AccessNortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 pathway
- Chunyang Zhu
- , Yangyang Lu
- & Weiwei Qi
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| Open AccessKSRP improves pancreatic beta cell function and survival
- Leticia Barssotti
- , Gabriela Moreira Soares
- & Helena Cristina Lima Barbosa
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| Open AccessSTAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation
- Yuichi Sekine
- , Kazuna Kikkawa
- & Tadashi Matsuda
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| Open AccessAryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer
- Jeffrey C. Martin
- , Tatiane da Silva Fernandes
- & Anna Bianchi-Smiraglia
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| Open AccessIFN-γ decreases PD-1 in T lymphocytes from convalescent COVID-19 patients via the AKT/GSK3β signaling pathway
- Meijuan Song
- , Xiangqun Liu
- & Ningfei Ji
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| Open AccessVAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma
- Natalia Fernández-Parejo
- , L. Francisco Lorenzo-Martín
- & Xosé R. Bustelo
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| Open AccessImmunological mechanisms of the nucleocapsid protein in COVID-19
- Fahime Edalat
- , Niloofar Khakpour
- & Afagh Moattari
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| Open AccessAmphetamine increases vascular permeability by modulating endothelial actin cytoskeleton and NO synthase via PAR-1 and VEGF-R
- Julia Böttner
- , Tina Fischer-Schaepmann
- & Petra Büttner
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| Open AccessElectric field modulation of ERK dynamics shows dependency on waveform and timing
- Minxi Hu
- , Houpu Li
- & Quan Qing
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| Open AccessExploring the association between rosacea and acne by integrated bioinformatics analysis
- Jingchen Liang
- , Ying Chen
- & Weihui Zeng
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| Open AccessDynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer
- Yuanhua Lu
- , Hui Li
- & Ying Cheng
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| Open AccessAlteration of actin cytoskeletal organisation in fetal akinesia deformation sequence
- Ramona Jühlen
- , Lukas Grauer
- & Birthe Fahrenkrog
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| Open AccessA computational model of stem cells’ internal mechanism to recapitulate spatial patterning and maintain the self-organized pattern in the homeostasis state
- Najme Khorasani
- & Mehdi Sadeghi
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| Open AccessRegulation of mitochondrial metabolism by autophagy supports leptin-induced cell migration
- Alin García-Miranda
- , José Benito Montes-Alvarado
- & Paola Maycotte
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| Open AccessShikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
- Hu Tuo
- , Wenjing Li
- & Lin Jin
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| Open AccessmiR-195b is required for proper cellular homeostasis in the elderly
- Maria del Mar Muñoz-Gallardo
- , Carlos Garcia-Padilla
- & Diego Franco
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| Open AccessThe follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells
- Amel Lounas
- , Yann Breton
- & François J. Richard
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| Open AccessEffect of hormone-induced plasma membrane phosphatidylinositol 4,5-bisphosphate depletion on receptor endocytosis suggests the importance of local regulation in phosphoinositide signaling
- Dániel J. Tóth
- , József T. Tóth
- & Péter Várnai
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| Open AccessNotch intracellular domains form transcriptionally active heterodimeric complexes on sequence-paired sites
- Tana R. Gazdik
- , Jacob J. Crow
- & Allan R. Albig
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| Open AccessUbiquinol attenuates γ-radiation induced coronary and aortic changes via PDGF/p38 MAPK/ICAM-1 related pathway
- Walaa A. El-Sabbagh
- , Noha A. Fadel
- & Laila A. Ramadan
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| Open AccessEGFR activation differentially affects the inflammatory profiles of female human aortic and coronary artery endothelial cells
- Virginie Dubourg
- , Gerald Schwerdt
- & Michael Gekle
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| Open AccessGα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion
- Olga Meiri Chaim
- , Shunichiro Miki
- & Joan Heller Brown
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| Open Accessβ-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling
- Hyung-Su Kim
- , Hyoung-June Kim
- & Si-Young Cho
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| Open AccessNectin-4 regulates cellular senescence-associated enlargement of cell size
- Ryoko Katasho
- , Taiki Nagano
- & Shinji Kamada
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| Open Access3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41
- Ryuji Ohue-Kitano
- , Yuki Masujima
- & Ikuo Kimura
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| Open AccessThe Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis
- Costanzo Padovano
- , Salvatore Daniele Bianco
- & Vincenzo Giambra
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| Open AccessAn arrayed CRISPR knockout screen identifies genetic regulators of GLUT1 expression
- Yajuan Shi
- , Ketaki A. Katdare
- & Ethan S. Lippmann
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| Open AccessScleral remodeling in early adulthood: the role of FGF-2
- Yingyan Qin
- , Taixiang Liu
- & Yao Ni
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| Open AccessTM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors
- Wataru Masuda
- , Tomoko Yamakawa
- & Motoo Kitagawa
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| Open AccessSingle-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma
- Sai Batchu
- , Khalid A. Hanafy
- & Ajith J. Thomas
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| Open AccessUnveiling the potential role of natriuretic peptide receptor a isoforms in fine-tuning the cGMP production and tissue-specific function
- Wei Fong Ang
- , Dan Liao
- & R. Manjunatha Kini
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| Open AccessKlotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury
- Agnieszka Olejnik
- , Anna Radajewska
- & Iwona Bil-Lula
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| Open AccessPPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation
- Chiaki Inoue
- , Kojiro Mukai
- & Tomohiko Taguchi
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| Open AccessRNF2 regulates Wnt/ß-catenin signaling via TCF7L1 destabilization
- Youngmu Koo
- , Wonhee Han
- & Jin-Kwan Han
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| Open AccessIL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages
- Tara E. Scott
- , Caitlin V. Lewis
- & Barbara K. Kemp-Harper