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The immunosuppressive metabolic tumour microenvironment in solid tumours limits the antitumour activity of cell-based immunotherapy. In this Perspective, McPhedran et al. propose a framework to overcome this issue by engineering metabolic networks in T cells to enhance chimeric antigen receptor T cell efficiency
Rosenbaum and Foster discuss the metabolic underpinnings of weight loss and weight loss maintenance, as well as the implications of considering them as distinct metabolic states for the treatment of obesity.
Lynch and colleagues give an overview of the classical roles of the cytokine IL-17 in host immunity, and look deeper into the emerging roles of IL-17 in cross-talk between the nervous system and gut and how IL-17 regulates and is regulated by systemic metabolic processes.
Cook and colleagues discuss the nature of hepatic insulin resistance and argue that liver hyperinsulinization (excessive hepatic insulin action) is a driver of hepatic steatosis.
This Perspective provides a concise overview of the diverse functions of vitamin K in physiology and metabolism, including its recently discovered role in ferroptosis.
The authors of this Perspective argue that the commonly used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ do not do justice to the diverse mitochondrial features, activities, functions and behaviours within cells, and thus call for the field to adopt more specific terminology in the context of mitochondrial biology.
The authors provide an overview of the current and emerging wearable and digital devices that can inform about specific metabolic outcomes in people, discussing how they could be used to create more tailored preventive and therapeutic strategies against cardiometabolic disease.
Nicholls and Brand present a bioenergetic critique of the futile creatine cycle as a mechanism for UCP1-independent diet-induced thermogenesis in brown adipose tissue.
In this Perspective, the authors discuss the various mouse preclinical models that are available for the study of non-alcoholic steatohepatitis (NASH) and NASH-induced hepatocellular carcinoma, and provide advice on reporting practices and how to select the most appropriate model.
The authors of this Perspective discuss the remarkable plasticity of the intestine in response to dietary and physiological changes, and highlight the importance of intestinal remodelling and metabolism in maintaining energy balance of the organism.
The authors of this Perspective summarize the state of human islet research and compare available islet procurement methods, proposing strategies to increase collaboration and standardization to accelerate discoveries on diabetes.
In this Perspective, Pekkurnaz and Wang offer an integrative overview on how mitochondrial homeostasis and diversity in morphology, distribution, composition and function contribute to meeting specific cellular demands, with a special focus on neurons
This Perspective summarizes the ongoing development of CAR-based therapies in indications beyond cancer, including for cardiometabolic diseases, fibrosis, autoimmune diseases and ageing.
Interleukin 6 is a pleiotropic cytokine that can be pro- or anti-inflammatory, depending on the metabolic context. Kistner et al. propose that these context-dependent effects are due to its adaptive role for short-term energy allocation, particularly during physical activity.
Bartman et al. provide a detailed review of techniques for measuring metabolic fluxes in intact mammals, how to analyse and interpret the results and how these techniques can be applied to investigate metabolism in vivo.
Quarta et al. discuss POMC neuronal heterogeneity and how specific subpopulations of POMC neurons can have diverse effects on appetite, whole-body metabolic physiology and the development of obesity.
Van Gastel and Carmeliet provide an overview of emerging findings on how cellular metabolism shapes skeletal stem cell fate and function, and discuss how metabolic dysregulation might contribute to skeletal ageing and degenerative diseases.
Zhang et al. discuss insights into the genetics of extreme human longevity and how genetics knowledge can be harnessed to guide the development of new therapies to extend human healthspan.
