Collection 

Dietary restriction and health

Submission status
Open
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Limiting food consumption, or the timing of food consumption, has been shown to have beneficial effects across a wide range of species, including yeast, worms, flies, rodents, non-human primates, and humans. Approaches to dietary restriction include the limitation of total caloric intake; the limitation of specific nutrients, particularly protein or select amino acids; or the temporal restriction of food intake, also known as intermittent fasting. In mammals, dietary restriction can increase healthspan and lifespan by protecting against ageing-related disorders such as cancer, neurodegenerative, cardiovascular, and metabolic diseases, and inflammation. The mechanisms underlying such effects include reduced insulin/IGF1 and mTORC1 signaling, reduced protein synthesis, reduced oxidative stress, and the activation of geroprotective sirtuins. Individuals can vary widely in their responses to various dietary restriction regimens, however, posing a challenge for translating these approaches to the clinic. 

This Collection welcomes original research on all aspects of dietary restriction, including the molecular pathways involved, the resulting health outcomes, and the factors affecting its efficacy.  

This Collection supports and amplifies research related to SDG 3.

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Intermittent fasting concept: white dinner plate used as a clock interface concept. Each timezone of the plate is covered with a fruit or vegetable. Asparagus symbolizes the minute and hours hands.

Editors

  • Yongting Luo, PhD , 

    Yongting Luo, PhD

    Department of Nutrition and Health, China Agricultural University, Beijing, China

  • Edyta Łuszczki, PhD , 

    Edyta Łuszczki, PhD

    Medical College of Rzeszów University, Rzeszów, Poland

  • Antonio Paoli, MD , 

    Antonio Paoli, MD

    Department of Biomedical Sciences, University of Padua, Padua, Italy

  • Mikiko Watanabe, MD, PhD  &

    Mikiko Watanabe, MD, PhD

    Sapienza University, Rome, Italy

  • Falak Zeb, PhD

    Falak Zeb, PhD

    University of Sharjah, Sharjah, UAE

Collections articles undergo Scientific Reports' standard peer review process and are subject to all of the journal’s standard policies. This includes the journal’s policy on competing interests. The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests. For more information, refer to our Collections guidelines.

 

This Collection has not been supported by sponsorship.