Dietary restriction and health
- Submission status
- Open
- Submission deadline
Limiting food consumption, or the timing of food consumption, has been shown to have beneficial effects across a wide range of species, including yeast, worms, flies, rodents, non-human primates, and humans. Approaches to dietary restriction include the limitation of total caloric intake; the limitation of specific nutrients, particularly protein or select amino acids; or the temporal restriction of food intake, also known as intermittent fasting. In mammals, dietary restriction can increase healthspan and lifespan by protecting against ageing-related disorders such as cancer, neurodegenerative, cardiovascular, and metabolic diseases, and inflammation. The mechanisms underlying such effects include reduced insulin/IGF1 and mTORC1 signaling, reduced protein synthesis, reduced oxidative stress, and the activation of geroprotective sirtuins. Individuals can vary widely in their responses to various dietary restriction regimens, however, posing a challenge for translating these approaches to the clinic.
This Collection welcomes original research on all aspects of dietary restriction, including the molecular pathways involved, the resulting health outcomes, and the factors affecting its efficacy.
This Collection supports and amplifies research related to SDG 3.
Editors
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Yongting Luo, PhD
Department of Nutrition and Health, China Agricultural University, Beijing, China
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Edyta Łuszczki, PhD
Medical College of Rzeszów University, Rzeszów, Poland
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Antonio Paoli, MD
Department of Biomedical Sciences, University of Padua, Padua, Italy
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Mikiko Watanabe, MD, PhD
Sapienza University, Rome, Italy
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Falak Zeb, PhD
University of Sharjah, Sharjah, UAE
