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This Perspective overviews the sources of prediction uncertainty in machine learning for applications in healthcare, and discusses how to implement suitable prediction-uncertainty metrics.
Antitumour responses mediated by T helper 17 cells can be induced by intratumourally injected hollow nanoparticles displaying the polysaccharide mannan.
Each of the 13 protein-coding genes in the mouse mitochondrial genome can be ablated using a library of optimized double-stranded-DNA deaminase-derived cytosine base editors.
The targeted delivery of the short-chain fatty acid butyrate to the lower gastrointestinal tract by polymeric nanoscale micelles restores intestinal homeostasis in mouse models of peanut allergy and colitis.
Liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules enable the mapping, via magnetic resonance imaging, of spatial variations of light intensity in illuminated brain tissue in living animals.
This Review highlights technological advances in exoskeleton technology from the past two decades, and challenges and opportunities in the exoskeleton-assisted rehabilitation of gait.
Pooled testing for the diagnosis of COVID-19 via isothermal nucleic acid amplification and detection can be automated by using electromagnetically actuated swarms of millimetric magnets to handle droplets of magnetized samples on a microfluidic chip.
This Perspective discusses the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease.
The inability to precisely manipulate mammalian mitochondrial DNA has stalled our understanding of mitochondrial biology and the generation of cellular and animal models in which to study it. DNA base editing technologies have enabled the generation of a library of mitochondrial base editors that precisely ablate every protein-coding gene in the mouse mitochondrial genome.
Water exchange through the transmembrane channel aquaporin-4 can be measured by conventional dynamic-contrast-enhanced magnetic resonance imaging and is a sensitive biomarker of the proliferation of gliomas and their resistance to chemotherapy.
Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.
Graph deep learning applied to multiplexed immunofluorescence data from tumour microenvironments reveals spatial cellular structures that are indicative of cancer prognosis.
Off-the-shelf microphones and earbud components connected to a smartphone can be as effective as an expensive clinical-grade device at measuring otoacoustic emissions to screen for hearing loss.
Developing gene therapy for use in the central nervous system has been hampered by the lack of an efficient vector for gene delivery. We report an adeno-associated virus vector with an enhanced ability to cross the blood–brain barrier in both rodents and non-human primates, and use it to develop systemic anti-tumour gene therapies for glioblastoma.
The flux of autophagosomes in heart tissue can be detected in live mice via the fluorescence and magnetic resonance properties of intravenously injected iron oxide nanoparticles decorated with fluorescent peptides cleavable by lysosomal cathepsins.
An assay leveraging strand-displacement reactions and enzymatic amplification for the recognition of viral RNA and implemented on origami paper allows for the fast colorimetric detection of SARS-CoV-2 variants, with single-nucleotide specificity.
