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Immunotherapy

Localized butyrate restores gut homeostasis

Nature Biomedical Engineering volume 7, pages 3–5 (2023)Cite this article

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The targeted delivery of the short-chain fatty acid butyrate to the lower gastrointestinal tract by polymeric nanoscale micelles restores intestinal homeostasis in mouse models of peanut allergy and colitis.

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Fig. 1: Butyrate preferentially released in specific regions of the GI tract by suitably designed nanoscale micelles delivered orally restores intestinal homeostasis in mouse models of intestinal inflammation.

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Authors and Affiliations

  1. Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Lu Wang & Jinyao Liu

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  1. Lu Wang
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  2. Jinyao Liu
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Correspondence to Jinyao Liu.

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Wang, L., Liu, J. Localized butyrate restores gut homeostasis. Nat. Biomed. Eng 7, 3–5 (2023). https://doi.org/10.1038/s41551-022-00994-z

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