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Successful pregnancy requires changes to the immune system to enable tolerance of the growing fetus. In this Review, the authors discuss how these immunomodulatory mechanisms contribute to the phenomenon of pregnancy-related improvement of rheumatoid arthritis.
Machine learning and high-throughput technologies hold promise for the classification, diagnosis and treatment of patients with rheumatic diseases, with the ultimate goal of precision medicine. Several studies in 2019 highlight the feasibility and clinical utility of using machine learning in rheumatology to stratify patients and/or predict treatment responses.