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Traditional management of osteoporosis has focused on a pharmacologic approach to treatment; however, for reasons such as potential adverse effects, some patients will not comply with medication regimens. This Review highlights the increasing evidence that valuable protection from fractures can also be derived from nonpharmacologic approaches.
Inflammasomes—large, intracellular complexes—receive input from Toll-like receptors and Nod-like receptors, and function to detect and respond to pathogens and genotoxic stress by processing pro-interleukin-1β to its active form. As well as providing an overview of inflammasomes, this article highlights some of the consequences of mutations in inflammasome components and aberrant processing of interleukin-1β.
