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In this Review, Schagen and colleagues discuss recent insights into the mechanisms underlying cognitive impairment that occurs after cancer treatment. The authors also discuss the steps necessary to develop restorative and preventive interventions for such impairment and provide recommendations for clinical care.
In this Review, the authors provide an overview of the evidence regarding the use of blood levels of glial fibrillary acidic protein as a biomarker in a range of neurological diseases, including traumatic brain injury, stroke, multiple sclerosis and Alzheimer disease.
In this Review, Fisher and Savitz consider how the era of reperfusion therapy in ischaemic stroke provides new hope for the development of cytoprotective therapies to further improve outcomes, highlighting how promising recent findings can be built on to benefit patients.
In this Review, the authors provide an overview of the clinical and pathological features of diseases caused by CGG trinucleotide repeat expansions, and propose that they represent a single underlying neuromyodegenerative syndrome with gene-dependent manifestations.
Two studies of the genetics of schizophrenia provide insight into somatic comorbidities and the potential of whole-genome sequencing in schizophrenia spectrum disorders, but highlight the need for more work to translate genetic findings into clinical benefits.
In this Review, the authors give an overview of the genetics of common small vessel disease, and provide insights into causal genes and the biological pathways involved, the overlap with monogenic small vessel disease, and the therapeutic implications of these factors.
Traditionally, CNS diseases have been classified into early-onset neurodevelopmental disorders and late-onset neurodegenerative disorders. However, as this article highlights, we now recognize that developmental and neurodegenerative disorders can involve shared mechanisms, with some classic neurodegenerative diseases also having a neurodevelopmental component.
Psychosis is a common symptom of Alzheimer disease (AD) and few treatments are available. In this Review, the authors describe the main features of psychosis in AD and other dementias and consider how recent mechanistic insights are informing new treatment approaches.
