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NEUROPSYCHIATRIC DISORDERS

Schizophrenia: genetic insights with clinical potential

Nature Reviews Neurology volume 18, pages 129–130 (2022)Cite this article

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Two studies of the genetics of schizophrenia provide insight into somatic comorbidities and the potential of whole-genome sequencing in schizophrenia spectrum disorders, but highlight the need for more work to translate genetic findings into clinical benefits.

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References

  1. Charlson, F. J. et al. Global epidemiology and burden of schizophrenia: findings from the Global Burden of Disease Study 2016. Schizophr. Bull. 44, 1195–1203 (2018).

    Article  Google Scholar 

  2. Smeland, O. B., Frei, O., Dale, A. M. & Andreassen, O. A. The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nat. Rev. Neurol. 16, 366–379 (2020).

    Article  Google Scholar 

  3. The Schizophrenia Working Group of the Psychiatric Genomics Consortium. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Preprint at https://www.medrxiv.org/content/10.1101/2020.09.12.20192922v1 (2020).

  4. Singh, T., Neale, B. M. & Daly, M. J. Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia. Preprint at https://www.medrxiv.org/content/10.1101/2020.09.18.20192815v1 (2020).

  5. Smeland, O. B. & Andreassen, O. A. Polygenic risk scores in psychiatry – large potential but still limited clinical utility. Eur. Neuropsychopharmacol. 51, 68–70 (2021).

    Article  CAS  Google Scholar 

  6. Zhang, R. et al. Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants. Mol. Psychiatry https://doi.org/10.1038/s41380-021-01387-5 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Alkelai, A. et al. The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders. Mol. Psychiatry https://doi.org/10.1038/s41380-021-01383-9 (2021).

    Article  PubMed  Google Scholar 

  8. Zheutlin, A. B. et al. Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four health care systems. Am. J. Psychiatry 176, 846–855 (2019).

    Article  Google Scholar 

  9. Frei, O. et al. Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nat. Commun. 10, 2417 (2019).

    Article  Google Scholar 

  10. Mukai, J. et al. Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice. Neuron 104, 471–487.e12 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

    Olav B. Smeland & Ole A. Andreassen

  2. KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway

    Ole A. Andreassen

Authors
  1. Olav B. Smeland
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  2. Ole A. Andreassen
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Corresponding author

Correspondence to Ole A. Andreassen.

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Competing interests

O.A.A. is a consultant to HealthLytix and has received speaker’s honoraria from Lundbeck and Sunovion. O.B.S. declares no competing interests.

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Smeland, O.B., Andreassen, O.A. Schizophrenia: genetic insights with clinical potential. Nat Rev Neurol 18, 129–130 (2022). https://doi.org/10.1038/s41582-021-00613-6

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