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This Review from Tansey and colleagues explores how an ageing immune system, host genetics and exposure to various environmental stressors combine to promote the development of Parkinson disease.
Here, Malek and colleagues describe the multiple ways in which IL-2 biologics have been engineered to preferentially target regulatory T cells or effector T cells, memory T cells and natural killer cells to correct dysregulated or insufficient immune responses in the settings of autoimmunity or cancer.
This Review from Masters and colleagues highlights how damage to intracellular organelles is linked to activation of the innate immune system. The authors propose that a better appreciation of such organellar homeostasis could lead to the identification of novel innate immune pathways and have therapeutic implications.
Alt and colleagues review recent advances in our understanding of the mechanistic role of cohesin-mediated chromatin loop extrusion in V(D)J recombination and class-switch recombination at the immunoglobulin heavy chain locus.
