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This Analysis considers the potential benefits and challenges of applying engineered nanoparticles for artificial-ocean-fertilization-driven carbon sequestration
An optical signal transduction pathway through feedback-controlled homeostatic temperature oscillations and mechanoresponse enables dynamic functionalities in a hydrogel.
Downregulation of specific proteins named scramblases might enhance tumour immunosuppression. In this paper the authors first show that the scramblase Xrk8 is overexpressed in tumour cells upon treatment with chemotherapeutics, and then develop a nanomedicine platform for co-delivery of a cancer prodrug and an siRNA directed against the Xrk8 gene, showing therapeutic effect and enhanced immune response in animal tumour models.
Solid tumours are less responsive to immunotherapies than haematological tumours due to specific biological differences. In this paper the authors propose a strategy to decorate the cell membrane of solid tumours with a protein typically present on haematological tumour cells that promotes phagocytosis of cancer cells, and show that this results in an increased immunotherapy efficacy in animal models of solid tumours.
Engineering of the interfacial properties between a semiconducting thin film and a stretchable substrate using tough interfacial bonding enables a notable delay in microcrack formation.
Homochiral helical toroids with micrometre-scale lengths are successfully fabricated by a combined solution–interface-directed hierarchical self-assembly strategy.
The interfacial shear modulus controls the sliding friction of supported two-dimensional materials. Now, experiments demonstrate a reciprocal relationship between friction force per unit contact area and the interfacial shear modulus.
Magnetic textures at the nanoscale are usually hard to resolve. This high-resolution electron microscopy method enables the imaging of the internal structure of magnetic textures with higher resolution and precision than the optical limit of the instrument.
Low-noise amplification of feeble microwave signals is essential for superconducting quantum circuitry. Now, a gate-tunable Josephson parametric amplifier made from graphene shows 24 dB amplification paired with 10 MHz bandwidth and –130 dBm saturation power.
Raman scattering within plasmonic waveguides is found to be directed into a single mode with near-unity efficiency, offering a route to broadband SERS enhancements over extended sensing volumes.
The reversible percolation of a graphene filler network in a liquid crystalline elastomer matrix enables the realization of mammalian-muscle-like actuation.
Activation of the stimulator of interferon genes (STING) can induce immunity in various cancer therapies, but delivery of STING agonists to tumours is challenging. Now a metal-based polymeric nanoparticle delivers STING agonists to tumours upon disruption of endothelial cells in tumour vasculature and targets tumour-associated macrophages, eliciting anti-tumour immune response in hard-to-treat cancer models.
Parametric amplifiers enable the low noise readout of systems with intrinsically low energy scales. Now, a parametric amplifier leveraging a graphene Josephson junction exhibits a gate-tunable working frequency and a gain exceeding 20 dB with added noise close to the standard quantum limit.
Twisting bilayer graphene to specific angles can yield correlated phases. A superconducting quantum interference device made from this magic-angle twisted bilayer graphene makes it possible to control the phase drop across a Josephson junction in this material.