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Mechanically rigid and geometrically stable nano-scaffolds decrease intermembrane spacing at the immunological synapse, leading to the exclusion of tyrosine phosphatase CD45 protein and enhancement of T-cell signalling.
The authors developed a highly conductive and dielectric composite solid-state electrolyte by coupling BaTiO3 and Li0.33La0.56TiO3–x nanowires with a side-by-side heterojunction structure in a polyvinylidene difluoride matrix, which simultaneously promotes the dissociation of lithium salts to produce more movable Li ions and efficiently transports the generated movable Li ions.
Strong intrinsic spin–orbit interaction unlocks the potential of circuit quantum electrodynamics with hole spins in silicon, resulting in strong spin–photon coupling of 300 MHz.
Thickness-dependent photoluminescence quantum yield measurements in black phosphorus reveal a free-carrier to excitonic transition, differing from the behaviour of conventional semiconductors.
Electrostatically defined quantum dots in graphene constitute a testbed to study atomic and molecular physics in the ultrarelativistic regime—when the particle speed is close to the speed of light. Magnetic-field-dependent tunnelling spectroscopy experiments now reveal giant orbital magnetic moments and paramagnetic shifts in single and double quantum dots due to their relativistic nature.
A large-scale pharmacophore model supported by in vitro ligand-binding studies suggests polylactic acid oligomer toxicity in a mouse model is due to the inhibition of matrix metallopeptidase 12.
RNA nanostructures can be designed to fold during transcription, but the solution structure has remained elusive. Here the authors use cryogenic electron microscopy to determine the structure of a panel of RNA origami shapes and uncover the design and folding principles.
An ultralong-range coupling was demonstrated between photonic lattices in bilayer and multilayer moiré architectures, which is mediated by dark surface lattice resonances in the vertical direction.
Using genetically tailored protein-based nanoprobes and taking advantage of image-segmentation-based machine learning, a high-throughput assessment of vascular permeability of individual blood vessels in 32 different tumours is quantified. These insights are valuable in developing personalized anticancer nanomedicine therapeutics and strategies modulating vascular permeability to treat tumours.
Reflection interference microscopy provides dynamic, non-invasive, operando imaging capabilities that enable the solid–electrolyte interphase formation and evolution of a battery to be mapped in real time with high sensitivity.
Quantification of the accidental release rates of engineered nanomaterials (ENMs) would inform risk management strategies and their implementation, but a comprehensive assessment of ENM accidental release is not currently available. Here the authors present a predictive study of the release of ENMs following accidents during their fabrication, transport and end-of-life processes in the next 10 and 30 years, based on conceptual models inspired by the nuclear power sector.
Aligning magic-angle twisted bilayer graphene to boron nitride layers introduces a gate hysteresis coexisting with its strongly correlated phases. This bistability enables electrical switching between superconducting, metallic and insulating states.
A donor–acceptor molecule assembles with different molecular packing to form photocatalysts which selectively produce either H2 or H2O2, depending on the aggregate structure, a proof-of-concept of photoactivity polymorphism.
Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. Here we use a bottlebrush prodrug platform to show that the delivery of three drugs in a synergistic combination in animal models outperforms other combinatorial approaches for multiple myeloma therapy.
Optically active semiconductor quantum dots have so far suffered from nuclear inhomogeneity limiting all dynamical decoupling measurements to a few microseconds. Lattice-matched GaAs–AlGaAs quantum dots now enable decoupling schemes to achieve a 0.11 ms spin coherence time.
Topological magnetic monopoles are non-local spin textures that are robust to thermal and quantum fluctuations, but they are difficult to study at the nanoscale in real space. Now, soft X-ray vector ptycho-tomography is demonstrated to determine the three-dimensional magnetization vector and emergent magnetic field of such magnetic monopoles in a ferromagnetic meta-lattice.