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Topological insulators possess edge states protected from disorder and can be realized in real materials as well as in synthetic materials based on optical, acoustic or mechanical characteristics. In addition to the spin, the orbital degree of freedom now provides an extra handle for manipulating topological phases.
A metasurface comprising electrically controlled heating units and a phase-change material offer non-volatile and reversible modulation of reflectance by more than fourfold.
Surgical resection is the primary treatment strategy for glioblastoma multiforme, but the infiltrating nature of the tumour, coupled with its heterogeneity and the presence of the blood–brain barrier that hampers drug delivery, contributes to recurrence and poor prognosis. Here the authors engineer a mechanically flexible mesh that can adhere to the tumour resected cavity and release a combination of nanomedicines and small molecules in a controlled and sustained manner for tumour therapy.
Ultra-high-frequency radio-frequency acoustic molecular imaging is a safe molecular imaging diagnostic option because it does not require radioactive probes or high magnetic fields, but lack of biocompatible targeted contrast agents has so far limited its in vivo application. In this paper the authors present perfluorocarbon nanodroplets containing hypertonic saline solution for targeted molecular imaging of prostate cancer in animal models.
Expansion microscopy, or ExM, physically expands biological specimens upon embedding them in swellable polymeric hydrogels, allowing nanoscale imaging using conventional microscopes. This work presents a diamond lattice polymeric hydrogel synthesized via click chemistry, which achieves higher homogeneity than the ones currently in use, allowing a more accurate sample expansion.
By incorporating an atomically defined HgS interlayer at the core/shell interface of CdSe/CdS quantum dots, these normally visible-light emitters can be converted into spectrally tunable, near-infrared fluorophores that exhibit excellent light-emission characteristics under both optical and electrical excitation.
Self-assembly of small drugs with organic dyes represents a facile route to synthesize nanoparticles with high drug-loading capability. Here the authors combine a machine learning approach with high-throughput experimental validation to identify which combinations of drugs and excipient lead to successful nanoparticle formation and characterize the therapeutic efficacy of two of them in vitro and in animal models.
While two-dimensional semiconductors enable the investigation of light–matter interactions in low dimensions, a link to magnetic order has so far remained elusive. Now, the antiferromagnetic insulator NiPS3 is found to exhibit excitons with strong linear polarization that are coupled to the zigzag antiferromagnetic order.
In this work, the authors develop a platform that leverages extracellular vesicles to measure drug–target engagement and apply it to monitor the outcomes of targeted treatments in lung cancer patients.
Interferometers can probe the wave-nature and exchange statistics of indistinguishable particles. Quantum Hall interferometers from graphite-encapsulated graphene heterostructures now enable the observation of the Aharonov–Bohm effect and of robust fractional quantum Hall states.
A defect-engineering strategy exploiting dithiolated molecules enables the formation of covalently interconnected networks based on solution-processed transition metal disulfides, leading to devices with enhanced electrical performance and improved characteristics.
Similar to optical waves, electrons can also interfere, but they require high-quality devices with minimal scattering for an experimental observation of this effect. An interferometer based on a single sheet of graphene provides an alternative to the more standard semiconductor devices and may in future enable access to exotic quantum effects, such as anyon braiding.
A three-dimensional continuous rotation electron diffraction method allows atomistic characterization of the chemistry of curved layered cathode materials.
The resonance of highly doping lanthanide ions in NaYF4 nanocrystals enhances the permittivity and polarizability of nanocrystals, leading to enhanced optical trapping forces by orders of magnitude, bypassing the trapping requirement of refractive index mismatch.
Understanding the in vivo biotransformation of nanomaterials used for biomedical applications might shed light on their long-term effects and safety. Here the authors show that molybdenum derived from nanomaterials is mainly transported in the liver, in a corona-mediated process, and is incorporated in molybdoenzymes, with an effect on liver metabolism.