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Nanoparticle clearance is critical for safety and therapeutic applicability. Here the authors report the modulatory role of microglial extracellular vesicles on the brain clearance of organic and inorganic nanoparticles and provide a strategy to control their intracerebral fate.
Fluorinated elastomers as photoresists in the fabrication of soft neural probes are used to enhance the spatiotemporal recording capability at single-neuron resolution within the central nervous system of rodents.
Using hydrogel nanovials to capture single mesenchymal stromal cells and their growth factor secretions, the authors link cell secretion to the transcriptome for thousands of cells, SEC-seq, enabling the study of secretion-associated cell states and mechanisms in therapeutic cell types.
The interference between two frequency-degenerate upconversion processes enables a metasurface-based, all-optical routing by controlling the phase delay between pump beams.
The level of immune response in cancer vaccines can limit application. Here, an immune mobilization strategy, using bacteria-derived nanovesicles, enhances therapeutic outcomes of tumour vaccination by stimulating interleukin-1β secretion to elicit trained immunity with lineage shifts and epigenetic changes in myeloid progenitor pools.
High-energy interlayer excitons in van der Waals semiconducting transition metal dichalcogenides lie far above the bandgap and emit in the ultraviolet range.
Resonant laser excitation is used to control the charge states of colour centre clusters in diamond with sub-diffraction resolution. These states are long-lived and can be read out non-destructively with low energy consumption.
Ion–ion interactions are crucial to the functioning of biological and artificial ion channels. Here the authors reveal that hydrated alkali metal ions can form one-dimensional closely packed chain structures at charged surfaces to facilitate ion transport.
Combined theoretical and experimental efforts provide systematic insights into the origin of self-switchable conductivity in layered semiconductor ferroelectrics. These mechanistic findings may enable advanced logic-in-memory devices.
Native-nanoBleach, a single-molecule imaging technique with a spatial resolution of ~10 nm, quantifies the oligomeric distribution of membrane proteins directly from native membranes at endogenous expression levels with their proximal native membrane environment using amphipathic copolymer nanodiscs.
Mechanistic origins of force stability and bond kinetics of interaction of the receptor-binding domain from the SARS-CoV-2 spike protein with angiotensin-converting enzyme 2, a key selection factor for mutations, are revealed at the single-molecule resolution using magnetic tweezers and molecular dynamics simulations.
The development of a tandem catalyst, consisting of two distinct nanoscale-engineered layers, enables efficient multicarbon production with high CO2 utilization in an acidic CO2 electroreduction environment.
Stacking graphene in the rhombohedral order to the tetralayer yields stronger Coulomb interactions, which results in insulating and metallic states with spontaneous symmetry breaking in spin, valley and layer degrees of freedom.
Nebulized mRNA delivery has broad therapeutic potential but has proven challenging. Here, the authors report on a modified lipid nanoparticle with improved conditions to allow nebulization and demonstrate its application for delivering mRNA to the lungs.
Catalytic metals dissolved in a liquid gallium solvent remain atomically dispersed. Alignments among the liquid atoms and reactants facilitate selective propylene synthesis from various hydrocarbon feedstocks.
Here the authors show that the trophi or jaws of the chitinous masticatory apparatus of marine and freshwater zooplankton rotifers can grind microplastics, independent of polymer composition, and generate particulate nanoplastics, which may accelerate the nanoplastic flux in global surface waters.
Synthetic nanoparticles coated with cell membranes show immune evasion and circulate longer. Here, a genetically engineered cell membrane expressing a SpyCatcher anchor is used as a modular nanotherapeutic drug delivery platform for high-affinity targeting and suppression of ovarian cancer.
Rheumatoid arthritis involves both inflammation and immune dysfunction, yet most therapies only target one aspect. Here, the authors report on ceria nanoparticle vesicle hybrids producing anti-inflammatory action and immunomodulation to relieve symptoms and restore normal function.
A nanoscale DNA origami turbine is shown to perform mechanical rotation by directly harvesting transmembrane potential energy from an ion-concentration gradient across a solid-state nanopore. The direction of rotation is set by the designed chiral twist in the turbine’s blades.
A major limiting factor for nonlinear efficiencies in lithium niobate waveguides, nanoscale thickness inhomogeneity, has been tackled using a fabrication approach called adapted poling.