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Dhamija et al. profile 3,412 nonstop mutations from 62 tumour entities and as proof of concept demonstrate that six such mutations cause degradation and loss of the tumour suppressor SMAD4.
Massou et al. combine cell stretching, super-resolution imaging and single-protein tracking to investigate integrin-based mechanosensing in live cells.
Sato et al. demonstrate that IRF2, which negatively regulates interferon signalling, safeguards intestinal stem cells against non-infectious, sterile interferon stress by limiting their differentiation into secretory lineages.
After lung injury, Kobayashi, Tata et al. find an intermediate cell state during the transition of alveolar type-2 into type-1 cells that is associated with senescence, controlled by TP53 and persists in fibrosis.
Vietri et al. show that the micronucleus fails to restrain ESCRT-III spreading due to its small size, resulting in aberrant accumulation of ESCRT-III to drive micronuclear collapse and DNA fragmentation.
López-Hernández et al. show that exo-endocytosis of a Na+/H+ exchanger controls lysosome biogenesis through Ca2+/calcineurin-mediated activation of TFEB in response to osmotic stress.
Burton et al. show that H3K9me3 deposition catalysed by SUV39H2 and regulated by pericentromeric RNAs in the mouse paternal pronucleus does not suppress gene expression, but bookmarks promoters for compaction.
Cao et al. show that SPIN90 enhances formation of Arp2/3-mediated unbranched filaments and promotes a formin-based cortex by recruiting mDia1 or forming a ternary SPIN90–Arp2/3–mDia1 complex.
Hsu et al. find that the protein kinase Akt acts as a co-adaptor in the clathrin coat complex and is needed in conjunction with ACAP1 to bind to cargo proteins to promote their recycling.
Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.
Roider et al. combine scRNA-seq and transcriptome-informed flow cytometry, and uncover transcriptionally different malignant subclones with distinct drug responses and T-cell profiles in B-cell non-Hodgkin lymphoma.
Bischof and colleagues report that AP-1 bookmarks prospective senescence enhancers for future activation to achieve a timely execution of the senescence programme.
Tumour fibroblasts influence oncolytic viral therapy. Arwert et al. show that transcytosis of cancer cells into fibroblasts activates STING and IRF3 to upregulate interferon-β1, eliciting a transcriptional program to reduce the effectiveness of oncolytic viral therapy.
Exon–intron-fused RAB22A regulates metastasis of osteosarcoma. Liao et al. show that protein products resulting from chromosomal translocations involving RAB22A mediate release of GTP-bound RhoA, induce its activation and promote lung metastasis of osteosarcoma.
Dehapiot et al. show two actin networks at the cell surface in Drosophila embryos. While the pulsatile network controls local deformation, the Frl-dependent persistent network promotes force propagation.
Boyle et al. show that ROCK upregulates PERK signalling in epithelia of breast cancer, thereby enhancing recruitment and function of cancer-associated fibroblasts through CRELD2 to promote tumourigenesis.
Baksh et al. show that oncogenic epidermal stem cells require extracellular serine to initiate squamous cell carcinoma via altering dioxygenases that remove H3K27me3.
Zhang et al. show that dynamin forms a helical structure with actin and, upon disruption, enhances branched actin polymerization, constituting a dynamic cycle to regulate actin cytoskeleton mechanical strength.
Bi et al. reveal a coordinated function for GATA3 and AP1 in altering enhancer landscapes, thereby promoting a basal/mesenchymal phenotype and endocrine resistance in breast cancer.
Li and colleagues report base editor variants with improved targeting efficiencies and broader editing windows by fusing the original base editors with the single-stranded DNA-binding domain of Rad51.