Reviews & Analysis

Transcription factors containing disordered regions can now be mapped across the genome, aiding functional studies.

Human glial progenitors transplanted into a chimeric mouse brain replace sick or older human glia, a finding that could one day lead to new treatments for neurological disease.

An automated system for picking bacterial colonies is used to create a biobank of personalized microbiomes.

Gene editing boosts the yields of sorghum, rice and millet grown in alkaline soils.

Single-cell data from RNA-seq, chromatin accessibility, DNA methylation and other modalities can be readily integrated using two new methods.

SEACells identifies rare cell states in large datasets, enabling atlas-scale studies.

Dual sequencing of the epigenome and genome could have broad implications in oncology.

CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles.

Functional proteins with limited homology to natural proteins are designed using a large language model.

Edited, transgene-free plants are produced without tissue culture by RNA migration from rootstocks to grafts.

Elongating protein fibers record the transcriptional activity of single cells for later readout by imaging.

Bioinformatic mining and engineering of serine recombinases yields improved genome editing tools.

Super-resolution microscopy at ångström precision could pave the way to optical structural biology in cells.

New methods for mapping the mRNA modifications N⁶-methyladenosine and pseudouridine enable large-scale functional analyses.

Protein structure prediction with a language model improves accuracy for orphan and designed proteins.

Logic-gated monoclonal antibodies have been designed to improve safety and efficacy.

An influenza vaccine is created by attenuating the live virus through targeted proteolysis.

Reprogramming of antibody responses in mice is achieved via adeno-associated virus delivery of SaCas9, single guide RNA (sgRNA) and a repair template targeting immunoglobulin genes.

CRISPR base- and prime-editing pooled screens reveal the function of genetic variants at unprecedented resolution.

Artificial intelligence finds candidate peptide antibiotics in the human gut microbiome.