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Mood dysfunction is more common in people with brain tumors than in those with other tumor types, but the reasons for this association are unclear. Using various methods for lesion–symptom mapping, we identified brain locations in patients with diffuse glioma that are related to severe depressive symptoms or an absence of depressive symptoms.
This Review explores the link between mood disorders and circadian disruptions, including social jet lag and shift work, and offers new perspectives for therapeutic development in future chronobiology research.
Postpartum depression (PPD) is a major public health concern, yet we lack tools to predict PPD during pregnancy. We found that lower sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle response, can predict risk of PPD in women who were not depressed during their pregnancy.
This Review discusses the key factors that comprise the mental load of motherhood and the need to provide support for a healthy transition to motherhood.
In this Perspective, the authors present an integrative model aimed at understanding and explaining the mechanisms that account for the impact of stigma on the mental health of multiple marginalized populations.
This Perspective discusses the importance of increasing access to psychedelic-assisted therapy to sexual and gender minorities and proposes a theoretical framework integrating minority stress theory to inform the research and guide study design.
In this Review, the authors discuss the neurobiological mechanisms of motor cortex-related analgesia, drawing insights from both experimental data and clinical data.
In this Perspective, authors argue for a more robust and comprehensive postmarket surveillance program of psychedelic-assisted psychotherapy to better ensure safe, appropriate and equitable care for patients.
In this Perspective, the authors make recommendations on better aligning stakeholders, including those in technology, practitioners and researchers, to increase collaboration and governance in technology and mental health.
This Review discusses the specific challenges and strategies in supporting individuals with ADHD during the critical transition to adulthood and outlines arguments for engaging and training parents.
Using task-based functional MRI, we examined inpatients with heroin use disorder. We found that 15 weeks of medication-assisted treatment (including supplemental group therapy) improved impaired anterior and dorsolateral prefrontal cortex function during an inhibitory control task. Inhibitory control, a core deficit in drug addiction, may be amenable to targeted prefrontal cortex interventions.
In this Review the authors address the intersection between mental illness and homelessness in high-income countries, and propose policy and practice priorities to reduce homelessness and to improve health outcomes.
In this Perspective the authors provide recommendations for researchers conducting school-based mental health research to minimize potential harm in designing and delivering interventions.
Combining accelerometry, electronic diaries and neuroimaging, we found that physical activity is reproducibly linked to better wellbeing in people lacking social contact in everyday life, especially in people at neural and psychological risk of affective disorders.
In this Perspective, Minnis and co-authors propose a new framework, the bio-exposome, to integrate the multiple aspects of biological and exposome factors associated with childhood adversity that interact and influence outcomes for individuals across their lifespan.
Erritzoe et al. review the current evidence from neuroimaging studies on psychedelics and discuss how these data advance our understanding of their action.
In this Perspective the authors survey the state of computerized cognitive training interventions for mental health and identify some of the challenges and opportunities in the scale-up of certain interventions.
In this Review, the authors outline the current evidence on a precision medicine approach to Alzheimer’s disease risk reduction and propose how to integrate personalized strategies into routine clinical practice.
Inconsistent results have been obtained regarding the role of obesity and its related metabolic syndrome in neurological and psychiatric diseases. This systematic research using the UK Biobank demonstrates effects of body weight on the risk of several neurological and psychiatric disorders, and suggests that the higher risks may be partially explained by brain structure, food intake and inflammation.