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Using a card gambling task paired with intracranial recordings and deep brain stimulation of the right subthalamic nucleus, the authors dissociate objective and subjective markers of risk taking and demonstrate the role of stimulation localization on risk-related behavior.
In this study, analyzing Czech national register-based data and using genome-wide Mendelian randomization, the authors report elevated risk for developing substance use, mood, anxiety and personality disorders in individuals with childhood-onset type 1 diabetes, and show that these associations are unlikely to be explicable by common underlying biological mechanisms.
In this cohort study, the authors find that depressive symptoms at the beginning of the pandemic may partially explain why women participants who had a COVID-19 episode were more likely than their male counterparts to report at least one post-COVID-19 persistent symptom seven to ten months later.
In this study, the authors use a combination of genetic methodologies to investigate the genetic associations between attention-deficit/hyperactivity disorder, cannabis use disorder and cannabis use.
Using deep brain stimulation of the habenula with implanted electrodes in patients with treatment-resistant depression, this study found a substantial reduction in depression scores at follow-up over multiple time points.
The authors report how the anatomical location of diffuse gliomas is related to the occurrence of severe depressive symptoms or the absence of depressive symptoms.
Using a computational approach, Wu et al. find that autism-related traits are associated with reduced observational learning specifically through reduced goal emulation, revealing difficulties in social goal inference.
The authors demonstrate that, in a mouse model of heroin use disorder, co-administration of morphine and suvorexant prevented both morphine-induced anatomical changes in hypocretin neurons and morphine anticipation and reduced morphine withdrawal behavior but spared analgesia, suggesting applications for reducing opioid addiction potential in humans.
The authors investigate functional connectivity before and after transcranial magnetic stimulation in veterans with treatment-resistant depression stratified by cognitive biotype, demonstrating associated brain connectivity-mediated improvement in cognitive behavioral task performance.
In this study using UK Biobank and genomic data, the phenotypic and genetic factor structures across ten psychiatric conditions are analyzed, finding general genetic and phenotypic consistency but greater potential gene and environment disparities in conditions associated with externalizing disorders.
The authors used data from the ABCD Study to examine the effects of prenatal cannabis exposure on neuroimaging metrics and mental health in adolescents.
In this study the authors investigate whether prepulse inhibition, measured in late pregnancy, could predict depressive symptom status at 6 weeks postpartum.
Investigating the influence of using methamphetamine on the rate of admissions for mental health disorders, this study finds that concurrent methamphetamine use increased mental health-related hospital admissions 10.5-fold. Increased prevalence was also found for men, non-Hispanic Black people, middle-aged adults, and people living in the South.
The authors evaluated and integrated compositional and functional microbiota data using fecal samples taken from healthy individuals and multimodal neuroimaging.
The authors investigate neural oscillations, measured by magnetoencephalography, in response to emotionally valenced stimuli as a potential biomarker characterizing individuals with major depressive disorder who had previously made a suicide attempt.
In this Article, the authors investigate dissociable effects of dopaminergic medications and different depression symptom dimensions in patients with Parkinson disease, suggesting a role for dopamine agonists as a potential treatment.
In this Article, the authors present data showing that pregnant people seeking treatment for opioid use disorder who receive psychostimulant medication for attention deficit hyperactivity disorder were more likely to initiate and adhere to treatment with buprenorphine.
The authors investigate the association between stock market fluctuations as measured by daily market returns and emergency room visits for mental health disorders and physical illnesses, finding the greatest effects among older people and men.
The authors synthesize data from previous literature on observational, experimental and medicinal cannabis research to assess rates and predictors of cannabis-associated psychotic symptoms.