CANCER AND CELL SIGNALING

Cancer biology and cell signaling have been traditionally strong areas for Cell Research. This focus presents a collection of selected articles from various issues, and includes some of the most recent exciting discoveries published in the journal

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Reviews

Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy

Qi Zhang, Guihua Chen, Xinyuan Liu and Qijun Qian

Cell Res 17: 89–99; doi:10.1038/sj.cr.7310143

Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

Jun–Ping Liu, Lucy Cassar, Alex Pinto and He Li

Cell Res 16: 809–817; doi:10.1038/sj.cr.7310098

Hsp90 at the crossroads of genetics and epigenetics

Keith SK Wong and Walid A Houry

Cell Res 16: 742–749; doi:10.1038/sj.cr.7310090

The role of Toll-like receptors in non-infectious lung injury

Dianhua Jiang, Jiurong Liang, Yuhang Li and Paul W Noble

Cell Res 16: 693–701; doi:10.1038/sj.cr.7310085

Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases FREE

Sarah M Mense and Li Zhang

Cell Res 16: 681–692; doi:10.1038/sj.cr.7310086

Role of JNK activation in apoptosis: A double-edged sword FREE

Jing Liu and Anning Lin

Cell Res 15: 36–42; doi:10.1038/sj.cr.7290262

Wnt signaling in disease and in development FREE

Roel Nusse

Cell Res 15: 28–32; doi:10.1038/sj.cr.7290260

Activation and signaling of the p38 MAP kinase pathway FREE

Tyler Zarubin and Jiahuai Han

Cell Res 15: 11–18; doi:10.1038/sj.cr.7290257

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension FREE

Bing-e Xu, Byung-Hoon Lee, Xiaoshan Min, Lisa Lenertz, Charles J Heise, Steve Stippec, Elizabeth J Goldsmith and Melanie H Cobb

Cell Res 15: 6–10; doi:10.1038/sj.cr.7290256

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Original Articles

Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development FREE

Genji Qin, Zhiqiang Ma, Li Zhang, Shufan Xing, Xianhui Hou, Jie Deng, Jingjing Liu, Zhangliang Chen, Li-Jia Qu and Hongya Gu

Cell Res 17: 249–263; doi:10.1038/cr.2007.7

Cell polarity protein Par3 complexes with DNA–PK via Ku70 and regulates DNA double–strand break repair FREE

Longhou Fang, YiGuo Wang, Dan Du, Guang Yang, Tim Tak Kwok, Siu Kai Kong, Benjamin Chen, David J Chen and Zhengjun Chen

Cell Res 17: 100–116; doi:10.1038/sj.cr.7310145

Expression and regulation of IL–22 in the IL–17–producing CD4+ T lymphocytes

Yeonseok Chung, Xuexian Yang, Seon Hee Chang, Li Ma, Qiang Tian and Chen Dong

Cell Res 16: 902–907; doi:10.1038/sj.cr.7310106

Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK)

Guoliang Qing, Pengrong Yan and Gutian Xiao

Cell Res 16: 895–901; doi:10.1038/sj.cr.7310109

Deficit of mitochondria–derived ATP during oxidative stress impairs mouse MII oocyte spindles

Xiao Zhang, Xue Qing Wu, Shuang Lu, Ying Lu Guo and Xu Ma

Cell Res 16: 841–850; advance online publication, September 19, 2006; doi:10.1038/sj.cr.7310095

A new interaction between Abi–1 and betaPIX involved in PDGF–activated actin cytoskeleton reorganisation

Fanny Campa, Nikolaus Machuy, Alexander Klein and Thomas Rudel

Cell Res 16: 759–770; doi:10.1038/sj.cr.7310091

Coordinated peak expression of MMP–26 and TIMP–4 in preinvasive human prostate tumor

Seakwoo Lee, Kevin K Desai, Kenneth A Iczkowski, Robert G Newcomer, Kevin J Wu, Yun–Ge Zhao, Winston W Tan, Mark D Roycik and Qing–Xiang Amy Sang

Cell Res 16: 750–758; doi:10.1038/sj.cr.7310089

Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45beta FREE

Li Wang, Fang Du, Qi Cao, Huiming Sheng, Baihua Shen, Yan Zhang, Yingna Diao, Jingwu Zhang and Ningli Li

Cell Res 16: 702–712; doi:10.1038/sj.cr.7310083

Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cell FREE

Aili Li and Long Mao

Cell Res 16: 671–677; doi:10.1038/sj.cr.7310078

Plant fertility defects induced by the enhanced expression of microRNA167 FREE

Peng Ru, Lin Xu, Hong Ma and Hai Huang

Cell Res 16: 457–465; doi:10.1038/sj.cr.7310057

The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization FREE

Anne Benzinger, Grzegorz M Popowicz, Joma K Joy, Sudipta Majumdar, Tad A Holak and Heiko Hermeking

Cell Res 15: 219–227; doi:10.1038/sj.cr.7290290