Haematopoietic stem cells articles within Nature Materials

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• News & Views | 19 September 2019

  CRISPR genome editing in stem cells turns to gold

  Hematopoietic stem and progenitor cells have been engineered using gold nanoformulations conjugated with CRISPR capable of targeting two distinct genomic loci of therapeutic interest, with potential engraftment in humanized mouse models.

  • Aravind Asokan

• Article | 27 May 2019

  Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations

  Gold nanoparticles that passively deliver CRISPR machinery to blood repopulating cells have been developed and are shown to be capable of precise editing of multiple genetic loci of therapeutic interest without cytotoxicity or reduced fitness.

  • Reza Shahbazi
  • , Gabriella Sghia-Hughes
  •  & Jennifer E. Adair