Adult stem cells articles within Nature Materials

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• News & Views | 22 July 2019

  Mastering their own fates through the matrix

  With their ability to give rise to many different cell types, stem cells have long been a target of scientists who seek to achieve control over their differentiation. New evidence suggests that stem cells influence their own fates through protein deposition and physical remodelling of their microenvironment.

  • Eric L. Qiao
  • , Sanjay Kumar
  •  & David V. Schaffer

• News & Views | 21 May 2019

  A pulpy story

  Over-expression of a transcriptional factor, Alx3, has been shown to revitalize the regenerative capacity of adult progenitor cells to promote enhanced stromal vascularization and formation of parenchymal dental pulp tissue in vivo.

  • Sarah E. Millar

• Article | 21 May 2019

  Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix

  The Alx3 transcription factor, expressed in prenatal tooth development, is shown to revitalize adult progenitor cells in decellularized scaffolds, leading to enhanced parenchymal dental pulp and vascularized stroma regeneration in vivo.

  • Ling He
  • , Jian Zhou
  •  & Jeremy Mao