Haematopoietic stem cells articles from across Nature Portfolio

Scarfò, Randolph et al. perform transcriptomic analysis of 28- to 32-day human embryos and identify CD32 as a marker of haemogenic endothelial cells (HECs), thus providing a strategy to isolate HECs from human embryos and pluripotent stem cell cultures.

Maneix, Iakova and colleagues report that cyclophilin A is a chaperone for, and regulator of, intrinsically disordered proteins within haematopoietic stem and progenitor cells, with potential effects on ageing-like phenotypes and lineage commitment.

Antibody-mediated depletion of myeloid-biased haematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system.

Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.

Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into human hematopoiesis at unprecedented resolution. Integrating ‘-omics’ datasets with machine learning has yielded a high-resolution map of primary human bone marrow hematopoietic progenitor cells that supports the study of immune cell development, as well as the origins of disease.

We established a method to generate complex self-organizing bone marrow-like organoids (BMOs) via concomitant differentiation of human induced pluripotent stem cells. These BMOs consist of hematopoietic cells, stromal niche cells and de novo vascular networks. In addition, they contain multipotent hematopoietic stem and progenitor cells, as well as mesenchymal stem and progenitor cells; they model aspects of the three-dimensional bone marrow architecture and can be used to study developmental and aberrant hematopoiesis.