Cancer articles within Nature Materials

Featured

  • News & Views |

    The fabrication of a self-sustaining source of low-energy electrons in a single-atom layer could help unravel fundamental mechanisms of radiobiological damage and lead to improved cancer therapies.

    • Léon Sanche

  • Editorial |

    Materials-based imaging agents are attractive candidates for a diverse range of imaging modalities and combined imaging–therapy applications, but economic implications and practical concerns remain obstacles to their clinical translation.

  • News & Views |

    Detection of a wide range of tumours remains a challenge in cancer diagnostics. By exploiting changes in the tumour microenvironment, a pH-responsive polymeric nanomaterial enables ultrasensitive tumour-specific imaging in many types of cancer.

    • Daishun Ling
    • , Michael J. Hackett
    •  & Taeghwan Hyeon

  • Commentary |

    Nanoparticle-based imaging plays a crucial role in cancer diagnosis and treatment. Here, we discuss the modalities used for molecular imaging of the tumour microenvironment and image-guided interventions including drug delivery, surgery and ablation therapy.

    • Chun Li

  • News & Views |

    Pliable gels of fibrin, a fibrous protein involved in blood clotting and linked to cancer, select cells with high in vivo aggressiveness and 'stemness' from a pool of cancer cells.

    • Jae-Won Shin
    •  & Dennis E. Discher

  • Article |

    The sustained release of both hydrophilic and hydrophobic immunomodulators for metastatic melanoma by nanoscale liposomal polymeric gels administered intratumorally or systemically is demonstrated. It is also shown that such a co-delivery approach delays tumour growth and increases the survival of tumour-bearing mice, and that its efficacy results from the activation of both innate and adaptative immune responses.

    • Jason Park
    • , Stephen H. Wrzesinski
    •  & Tarek M. Fahmy

  • Article |

    Conventional methods for the selection of tumorigenic cells from cancer cell lines rely on stem-cell markers. It is now shown that soft fibrin gels promote the growth of colonies of tumorigenic cells from single cancer cells from mouse or human cancer cell lines, and that as few as ten fibrin-cultured cells can lead to the formation of tumours in mice more efficiently than marker-selected cells.

    • Jing Liu
    • , Youhua Tan
    •  & Bo Huang

  • News & Views |

    Enzyme-modified plasmonic nanoparticles that generate a signal that is larger when the concentration of the target molecule is lower can detect ultralow levels of the cancer biomarker prostate-specific antigen in whole serum.

    • Mikael Käll

  • Article |

    A nanocarrier—synthesized by the fusion of liposomes to spherical, nanoporous silica particles and subsequent modification of the lipid bilayer with targeting peptides and fusogenic peptides—shows the targeted delivery and controlled release of chemically diverse multicomponent cargos within the cytosol of certain cancer cells.

    • Carlee E. Ashley
    • , Eric C. Carnes
    •  & C. Jeffrey Brinker

  • Commentary |

    To deepen understanding and hasten the development of treatments, cancer needs to be modelled more accurately in vitro; applying tissue-engineering concepts and approaches in this field could bridge the gap between two-dimensional studies and in vivo animal models.

    • Dietmar W. Hutmacher

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