News & Views |
Featured
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Article |
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas
A hydrogel-based modular lymphoma organoid identifies how lymphoid microenvironment cues dampen the effect of MALT1 inhibitors and informs effective combination therapies to rescue the treatment response
- Shivem B. Shah
- , Christopher R. Carlson
- & Ankur Singh
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News & Views |
Synthetic scaffold for pancreatic organoids
A synthetic matrix recapitulates fundamental biological interactions of pancreatic cancer to facilitate the culture of mouse and human pancreatic organoids.
- Sohini Khan
- & Hervé Tiriac
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Article |
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
A synthetic hydrogel has been developed to mimic the physicochemical properties of pancreatic tissue and is shown to support the culture of pancreatic cancer organoids, revealing the role of laminin–integrin interactions in their growth.
- Christopher R. Below
- , Joanna Kelly
- & Claus Jørgensen
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Review Article |
Next-generation cancer organoids
This Review summarizes limitations in the current techniques used for patient-derived cancer organoid culture and highlights recent advancements and future opportunities for their standardization.
- Bauer L. LeSavage
- , Riley A. Suhar
- & Sarah C. Heilshorn
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News & Views |
Just dose it
A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.
- Twan Lammers
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Review Article |
Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases
This Review highlights approaches used to generate somatic cell-derived organoids for modelling epithelial tissue to understand disease progression and how they are employed in preclinical drug screening.
- Masayuki Fujii
- & Toshiro Sato
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News & Views |
Oncogenetic engagement with mechanosensing
Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.
- Sayan Chakraborty
- & Wanjin Hong
A synthetic tumour microenvironment