Featured
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Article |
Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy
An anticancer agent, olsalazine, conjugated to a cell-penetrating peptide has been synthesized and shows the ability to self-assemble intracellularly by the tumour-associated enzyme furin, with the potential for tumour therapy and chemical exchange saturation transfer magnetic resonance imaging in vivo.
- Yue Yuan
- , Jia Zhang
- & Jeff W. M. Bulte
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Editorial |
Believing in seeing
Materials-based imaging agents are attractive candidates for a diverse range of imaging modalities and combined imaging–therapy applications, but economic implications and practical concerns remain obstacles to their clinical translation.
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News & Views |
Lighting up tumours
Detection of a wide range of tumours remains a challenge in cancer diagnostics. By exploiting changes in the tumour microenvironment, a pH-responsive polymeric nanomaterial enables ultrasensitive tumour-specific imaging in many types of cancer.
- Daishun Ling
- , Michael J. Hackett
- & Taeghwan Hyeon
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Commentary |
A targeted approach to cancer imaging and therapy
Nanoparticle-based imaging plays a crucial role in cancer diagnosis and treatment. Here, we discuss the modalities used for molecular imaging of the tumour microenvironment and image-guided interventions including drug delivery, surgery and ablation therapy.
- Chun Li
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