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Hyperactivity in a subset of lateral septum neurons inhibits social reward processing and drives social avoidance following chronic social defeat in mice.
Deletion of Gabrb3, which encodes the β3 subunit of the GABAA receptor selectively in pyramidal neurons of developing mouse sensory cortex, increased contralateral connectivity, network synchrony and sensitivity to tactile stimuli, suggesting that this receptor is involved in refinement of interhemispheric sensory pathways.
Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder.
The increased tissue stiffness that results from the presence of Aβ aggregates activates microglial mechanosensitive PIEZO1 channels and drives Aβ engulfment, reducing plaque burden, synapse loss and spatial memory impairment in mice.
Barosensitive neurons in the medullary nucleus of the solitary tract can decrease wakefulness and increase non-REM sleep in mice through the same circuitry that regulates cardiovascular function.
Fluorescent sensors of molecular activity have revolutionized our knowledge of the brain. However, their signals report a reaction between the target and the sensor molecules rather than the activity of interest per se. Thus, understanding the location, sensitivity and imaging environment of a sensor should help to avoid misinterpretation of its readout.