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Schereret al. show that analysis of circulating tumour DNA can provide prognostic information and predict relapse in patients with diffuse large B-cell lymphoma.
This Opinion article discusses the recurring regulatory architecture that is both necessary and sufficient to maintain tumour cell state. Considering this architecture provides a valuable reductionist framework to study the genetic heterogeneity of human disease and to drive key translational applications.
Two papers have shown in mouse tumour models that targeting PI3Kγ in myeloid cells can reduce immune suppression and increase the efficacy of immune checkpoint inhibitors.
The four tissue inhibitors of metalloproteinases (TIMPs) regulate proteolysis of a vast range of matrix and cell surface proteins, affecting tumour architecture and cell signalling. This Review article analyses the role of TIMPs in cancer and their potential as targets and biomarkers.
Skauet al. demonstrate that the actin nucleating protein FMN2 generates a perinuclear actin and focal adhesion-based structure to protect the nucleus from damage during cell migration through confining 3D microenvironments.
This Opinion article discusses the various migration modes used by cancer cells in confining microenvironments and explains how understanding confined cancer cell motilityin vivo through the application of engineered in vitromodels could help to develop therapeutic approaches to prevent metastases.
Ovarian cancer comprises a broad range of histologically and genetically different tumours. In this Opinion article, Karneziset al. explore the different origins of ovarian cancers and how these contribute to our understanding of genetic and environmental risk to better prevent and treat these tumours.
This Opinion article discusses many controversial issues surrounding the connections of progestogens, which stimulate the progesterone receptor, to breast cancer risk and their possible therapeutic use in breast cancer.
Mathias Wenes and colleagues have studied metabolic changes in tumour associated macrophages (TAMs) and found that specific alterations of mTOR regulation through regulated in development and DNA damage response 1 (REDD1) results in defective blood vessel formation and increased metastasis.
A paper inNaturedescribes a highly specific and potent small molecule inhibitor of MCL1 that has single-agent activity and good tolerability in several cancer models.
