Kohlhapp et al. found that acute influenza infection accelerates cancer-specific death of immunocompetent mice injected with B16 melanoma cells. Infection caused CD8+ T cells to move from the tumour to the site of infection, thus allowing increased tumour growth; this could be reversed by treatment with programmed cell death protein 1 (PD1) antibodies. These results might explain the data that non-oncogenic infections increase cancer-specific death in patients.
References
Kohlhapp, F. J. et al. Non-oncogenic acute viral infections disrupt anti-cancer responses and lead to accelerated cancer-specific host death. Cell Rep. 17, 957–965 (2016)
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Seton-Rogers, S. The consequences of concomitant challenges. Nat Rev Cancer 16, 757 (2016). https://doi.org/10.1038/nrc.2016.135
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DOI: https://doi.org/10.1038/nrc.2016.135
