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A combination of quantitative optical spectroscopic techniques and synchrotron nanoprobe measurements enable a visualization of the nanoscale chemical, structural and optoelectronic landscape in halide perovskite devices.
De novo designed peptide with β-hairpin structure assembles to form a β-barrelled nanopore that can detect not only polynucleotides but also polypeptide chains at a single-molecule level.
Dense, short hydrophobic nanochannels have been restacked from two-dimensional quantum sheets to achieve both high areal and volumetric capacitance in thick electrodes under ultrahigh rates.
Diodes exhibit non-reciprocal current–voltage relations, that is, the resistivity depends on the direction of the current flow. Now an array of Josephson junctions with large spin–orbit interaction acts as the superconducting version of a diode, where dissipation-free supercurrent flows in one direction, but not the other.
Neutrophils are the first responders in acute inflammatory events such as acute respiratory distress syndrome and tend to home to lung capillaries during acute inflammation, where they can cause tissue damage by diapedesis and secretion of specific molecules. Here the authors show that nanoparticles coated with agglutinated proteins selectively target activated neutrophils in inflamed lungs and can be used for imaging and therapeutic purposes.
Cancer cells adopt a series of strategies to evade the immune response mounted by the organism against them. Here we find that tumour cells can hijack mitochondria from immune cells by forming physical nanotubes, and suggest that inhibiting this process might represent a potential immunotherapy approach.
Innate immune cells such as dendritic cells and macrophages can activate the adaptive immune system against cancer by presenting cancer-specific antigens, although this activity is severely limited in macrophages due to their intrinsic lysosomal cysteine protease activity. Here the authors show that a DNA nanodevice specifically targeted to macrophage lysosomes can inhibit cysteine proteases in these cells, restoring their antigen-presenting capability.
Steam disinfection of silicone-rubber baby teats can lead to steam etching and chemical modification of the teat surface. This can release micro- and nanoplastics and result in ingestion. The results suggested that by the age of one year, a baby could ingest more than 600,000 microplastics.
A retina-inspired two-dimensional material based retinomorphic device exhibits all-in-one perception, memory and computing capabilities for motion detection and recognition.
Processing silk through a molecular bonding design and scalable coupling reagent-assisted dip-coating method can lead to subambient daytime radiative cooling.
So far, only conventional field emitters based on a bulk W needle have achieved atomic resolution in electron microscopy. Here, through the integration of a passive collimator structure and micromanipulation-based alignment of the support needle, a LaB6 nanowire emitter yields stable emission under moderate vacuum conditions and allows for atomic-resolution images and high energy resolution.
While chimeric antigen receptor (CAR) T cell-based therapy has been approved for clinical use for certain types of blood cancers, it remains difficult to achieve precise spatiotemporal control of the elicited anti-tumour response. Here, the authors propose light-switchable CAR T cells that can be remotely activated by a nano-optogenetic approach, reducing unwanted side effects.
Trivalent arsenic (AsIII) is a clinically approved treatment agent for patients with promyelocytic leukaemia, but cannot be used for other types of leukaemia due to its toxicity. Here the authors show that different patient-derived leukaemia cells express CD71 and design a ferritin-based nanoparticle for specific delivery of AsIII to these cells, demonstrating substantially improved efficacy towards different leukaemia types in animal models, with reduced side effects.
Magnon-mediated angular-momentum flow in antiferromagnets may become a design element for energy-efficient, low-dissipation and high-speed spintronic devices. Here, terahertz emission measurements in magnetic multilayers unveil a superluminal-like magnon velocity of ~650 km s–1 in the antiferromagnetic insulator NiO at nanoscale distances.
Torsion-strained TaxTmyIr1−x−yO2−δ nanocatalyst with abundant grain boundaries is promising towards acidic oxygen evolution in practical proton exchange membrane electrolysers. The cost of H2 is estimated to be reduced to US$1 per kg.
Engineering the energy dispersion of polaritons in microcavities can yield intriguing effects such as the anomalous quantum Hall and Rashba effects. Now, different Berry curvature distributions of polariton bands are obtained in a strongly coupled organic–inorganic two-dimensional perovskite single-crystal microcavity and can be modified via temperature and magnetic field variation.
Nanoparticle-mediated photoporation is used to temporarily permeabilize cell membranes for intracellular delivery of macromolecules, but cell exposure to nanoparticles might cause cellular damage and hamper application of the technique to therapeutic cell engineering. Here the authors show that, under photothermal heating, nanofibre-embedded iron oxide nanoparticles can be used to deliver effector macromolecules to different types of cells, in a contactless manner, with no cellular toxicity or diminished therapeutic potency.