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Jan Vilcek relates how his work helped to identify some of the pleiotropic actions of tumor necrosis factor and contributed to the development of infliximab, the first medically useful tumor necrosis factor antagonist.
How have women fared at Harvard since the events of four years ago? Here, Judy Lieberman and Laurie Glimcher reflect on progress made and barriers still to be breached.
Is it possible to return from the industrial sector back to academia? Although academic scientists have traditionally perceived this to be akin to winning the Nobel prize, the personal experience of Ross Kedl suggests that the reality is something quite different altogether.
Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta cells are damaged and destroyed. Animal models have served a prominent function in the development of the present ideas of pathogenesis and approaches to therapy. This commentary addresses the utility and limitations of these models for facilitating the 'translation' of immunology research into clinical applications.
Anjana Rao recounts the contributions of two talented and productive postdoctoral fellows who purified and characterized the transcription factor NFAT.