Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Animal models of human type 1 diabetes

Nature Immunology volume 10, pages 129–132 (2009)Cite this article

Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta cells are damaged and destroyed. Animal models have served a prominent function in the development of the present ideas of pathogenesis and approaches to therapy. This commentary addresses the utility and limitations of these models for facilitating the 'translation' of immunology research into clinical applications.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Keymeulen, B. et al. N. Engl. J. Med. 352, 2598–2608 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Herold, K.C. et al. Diabetes 54, 1763–1769 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Voltarelli, J.C. et al. J. Am. Med. Assoc. 297, 1568–1576 (2007).

    Article  CAS  Google Scholar 

  4. Seewaldt, S. et al. Diabetes 49, 1801–1809 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Petersen, J.S. et al. Clin. Exp. Immunol. 134, 38–45 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Homann, D. et al. Immunity 11, 463–472 (1999).

    Article  CAS  PubMed  Google Scholar 

  7. Shoda, L.K. et al. Immunity 23, 115–126 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Ciháková, D., Sharma, R.B., Fairweather, D., Afanasyeva, M. & Rose, N.R. Methods Mol. Med. 102, 175–193 (2004).

    PubMed  Google Scholar 

  9. Taylor, J.A. et al. J. Immunol. 172, 2651–2658 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. Wicker, L.S., Todd, J.A. & Peterson, L.B. Annu. Rev. Immunol. 13, 179–200 (1995).

    Article  CAS  PubMed  Google Scholar 

  11. Appleby, M.W. & Ramsdell, F. Curr. Top. Microbiol. Immunol. 321, 151–168 (2008).

    CAS  PubMed  Google Scholar 

  12. Wan, Y.Y. & Flavell, R.A. Nature 445, 766–770 (2007).

    Article  CAS  PubMed  Google Scholar 

  13. Enée, E. et al. J. Immunol. 180, 5430–5438 (2008).

    Article  PubMed  Google Scholar 

  14. Serreze, D.V., Marron, M.P. & Dilorenzo, T.P. Ann. NY Acad. Sci. 1103, 103–111 (2007).

    Article  CAS  PubMed  Google Scholar 

  15. Steinman, L. Proc. Natl. Acad. Sci. USA 93, 2253–2256 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Burton, A.R. et al. Diabetes 57, 1321–1330 (2008).

    Article  CAS  PubMed  Google Scholar 

  17. Von Herrath, M.G., Dockter, J. & Oldstone, M.B. Immunity 1, 231–242 (1994).

    Article  CAS  PubMed  Google Scholar 

  18. Kurts, C. et al. J. Exp. Med. 186, 2057–2062 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Morgan, D.J. et al. Proc. Natl. Acad. Sci. USA 96, 3854–3858 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Dotta, F. et al. Proc. Natl. Acad. Sci. USA 104, 5115–5120 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Rewers, M., Norris, J. & Dabelea, D. Adv. Exp. Med. Biol. 552, 219–246 (2004).

    PubMed  Google Scholar 

  22. Sherry, N.A. et al. Diabetes 55, 3238–3245 (2006).

    Article  CAS  PubMed  Google Scholar 

  23. Cano, D.A. et al. Diabetes 57, 958–966 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Matthias von Herrath is with the Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.,

    Matthias von Herrath

  2. Gerald T. Nepom is with the Benaroya Research Institute, Seattle, Washington 98101, USA. matthias@liai.org,

    Gerald T Nepom

Authors
  1. Matthias von Herrath
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerald T Nepom
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

von Herrath, M., Nepom, G. Animal models of human type 1 diabetes. Nat Immunol 10, 129–132 (2009). https://doi.org/10.1038/ni0209-129

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0209-129

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing