Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In this study, Vande Voorde et al. investigate the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC). They present a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. With this approach, they show perturbations in methionine metabolism linked to APC deficiency, and identify adenosylhomocysteinase as an actionable therapeutic target.
In this study, the anti-anginal drug ranolazine is found to sensitize BRAF inhibitor-resistant melanoma to targeted therapy and immunotherapy by rewiring fatty acid oxidation and the methionine salvage pathway.
In this study, Wang, Xu et al. investigate the interaction of neutrophils and T cells in lymphoid tissues away from the tumour area, and how metabolic competition between these immune cell populations impairs anti-tumour immunity in the context of breast cancer.
Gnanaprakasam et al. study the amino acid requirements during different phases of T cell activation and show how asparagine restriction imparts opposing effects during early and late phases of T cell maturation through an NRF2-dependent mechanism.
Dietary methionine restriction has been reported to protect from cancer. Ji et al. describe a cancer-promoting effect of methionine restriction mediated by gut microbiota-induced sulfur deficiency and suppression of antitumour immunity.
Suchacki et al. show that serotonin suppresses human brown adipose tissue (BAT) activation, and that inhibition of the serotonin transporter (SERT) potentiates the suppressive action of extracellular serotonin on BAT by preventing serotonin uptake.
Huang et al. develop an interface to allow electrode-mediated stimulation of gene expression in human cells, utilizing direct current-generated reactive oxygen species to stimulate transgene expression downstream of the KEAP1–NRF2 biosensor. In a type 1 diabetic mouse model, this interface is demonstrated to ameliorate hyperglycemia by stimulating insulin expression.
Variants in the FTO gene locus are known to be associated with obesity, including rs1421085 T>C variant, and now it is shown in mouse knock-in models that this C-allele increases expression of the Fto gene in brown adipocytes and enhances brown adipose tissue thermogenesis and obesity resistance.
In this study, Morant-Ferrando, Jiménez-Blasco et al. show that fatty acid oxidation in astrocytes is necessary to maintain a specific configuration of the electron transport chain, which enables controlled production of reactive oxygen species that fine-tune neuron–glia metabolic coupling and support cognitive function.
Mao et al. show that deficiency in CRAT, a key determinant of metabolic flexibility, triggers type I interferon responses and AIM2 inflammasome activation by promoting the bile acid synthesis pathway in cardiomyocytes.
Propionate addition is a common strategy for production of valuable polyketides by supplying the substrate methylmalonyl-CoA in the industrial microbe Corynebacteriumglutamicum; however, propionate inhibits C.glutamicum growth, thus hampering polyketide production. In this study, Zhan et al. identify the reasons for propionate-elicited growth inhibition and metabolically engineer C.glutamicum to circumvent this roadblock and increase polyketide production.
In this study, Tai et al. provide insights into the metabolic and bioenergetic responses in the axonal compartment in the context of multiple sclerosis. Moreover, they show how upregulating the tricarboxylic acid cycle confers protection against neuroinflammation-induced energy deprivation.
Barreby et al. identify a distinct subpopulation of human resident liver myeloid cells that expresses factors that act in a protective fashion against oxidative stress associated with NAFLD.
Time-restricted feeding in the resting period is a potent dietary regimen to enhance running endurance in mice, by synchronizing rhythms of perilipin-5 in muscle tissues through involvement of the circadian clock.
Beals, Kayser et al. demonstrate that exercise, in conjunction with diet-induced weight loss, causes greater improvement in whole-body insulin sensitivity than matched diet-induced weight loss alone in people with obesity and prediabetes.
Alterations in the gut microbiome, as a result of treatment with the anti-diabetic drug acarbose or with antibiotics, are shown to extend healthspan and lifespan in a mouse model of Leigh syndrome.
In aneuploid cancer cells with high ROS levels, a mitotic NADPH upsurge is required for error-free mitosis and tumour progression and therefore constitutes a cell cycle-dependent metabolic vulnerability.
Marine cyanobacteria contribute to global carbon balance by fixing CO2 and the shift between CO2 fixation and ATP production requires fine-tuning its metabolic fluxes to light–dark cycles. These cycles can be very short in marine environments due to sea currents and fast adaptation is key to avoid futile cycles. In this study, Lu et al. provide a mechanistic insight into how this process is tightly regulated.
Single-cell transcriptomic analysis of human multipotent progenitor cells reveals that upon adipogenic stimulation, Wnt signaling regulates the generation of functional multipotent mesenchymal progenitors, named structural Wnt-regulated adipose tissue resident cells, which maintain the progenitor pool.