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This Review summarizes the development of optoacoustic imaging with acoustic resolution and wide-bandwidth ultrasound detection, and the applicability of this mesoscopic imaging modality in the label-free visualization of tissue pathophysiology.
Depletion of cells expressing the cell-membrane protein programmed cell-death protein-1 using an antibody-based toxin delays the onset of disease in a mouse model of diabetes and reverses paralysis in mice with experimental autoimmune encephalomyelitis, without compromising physiological immunity.
High-throughput nanoparticle synthesis combined with machine learning speeds up the exploration of structure–activity relationships for nanomedicines, as shown for spherical nucleic acids functioning as cancer-vaccine candidates.
An antibody-modified nanoparticle encapsulating a pH-sensitive taxane prodrug, and targeting an overexpressed receptor in tumours, improves the tolerability and anticancer efficacy of the active drug in multiple animal models.
Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.
Enhanced lysosomal degradation of the transmembrane protein programmed cell-death protein-1 ligand in tumour cells, enabled by blocking the protein’s post-translational lipid modification, promotes T-cell-mediated suppression of tumour growth in mice.
A bioprinted glioblastoma-on-a-chip model enables the evaluation of treatment responses for individual patients whose brain tumours resist standard chemoradiotherapy.
Large-area electrode arrays for epidermal electrophysiology offer new possibilities for the control of prosthetic devices and the monitoring of brain function.
Accurate and explainable detection, via deep learning, of acute intracranial haemorrhage from computed tomography images of the head is achievable with small amounts of data for model training.
An inexpensive assay that uses thermophoresis to concentrate cancer extracellular vesicles bound to aptamers specific for target proteins on the vesicles’ surface, can classify cancer patients according to cancer type and stage.
By compressing blood vessels and neurons, globular tumours in the brain can cause neuronal damage, which can be partially reversed by relieving the stress via tumour removal or by administering lithium.
A computationally designed small molecule inhibits the replication of prion-protein aggregates and ameliorates neurological symptoms in mouse and non-human-primate models of transmissible spongiform encephalopathy.
Human cardiomyocytes and mice edited to harbour gene variants found in patients with dilated cardiomyopathy reveal combinatorial genetic interactions that contribute to the complex genetic heritability of the disease.
Magnetic nanoparticles complexed with recombinant baculoviral vectors containing the CRISPR–Cas9 machinery enable the local magnetic activation of genome editing.
This Review discusses the factors that affect the phenotypes of mesenchymal stromal cells, and the need for standardized assays that provide quality assurance for clinical uses of the cells.
