Enhanced lysosomal degradation of the transmembrane protein programmed cell-death protein-1 ligand in tumour cells, enabled by blocking the protein’s post-translational lipid modification, promotes T-cell-mediated suppression of tumour growth in mice.
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PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
Nature Communications Open Access 24 August 2021
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Lefrancois, S. Tumour suppression by blocking palmitoylation. Nat Biomed Eng 3, 255–256 (2019). https://doi.org/10.1038/s41551-019-0383-6
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DOI: https://doi.org/10.1038/s41551-019-0383-6
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PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
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