Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A wearable electrochemical biosensor can continuously detect, in sweat during physical exercise and at rest, trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.
Concurrent frequency-domain diffuse optical spectroscopy and ultrasound imaging can be used to non-invasively monitor placental oxygen haemodynamics in pregnant women in real time.
A stretchable neuromorphic ‘nerve’ restores coordinated and smooth motions in the legs of mice with neurological motor disorders, enabling the animals to kick a ball, walk or run.
A miniaturized one-photon endoscope integrating digital micromirrors allows for simultaneous optogenetic stimulation and calcium imaging of identified neurons in freely behaving mice.
A COVID-19 test implemented in an automated microfluidic device and leveraging isothermal RNA amplification followed by T7 transcription and Cas13-mediated cleavage of a quenched fluorophore rapidly detects SARS-CoV-2 RNA in saliva samples.
A 3D-printed lab-on-a-chip allows for the concurrent rapid electrochemical detection of SARS-CoV-2 RNA in saliva and of anti-SARS-CoV-2 antibodies in saliva spiked with blood plasma.
Potent allogeneic CD8αβ+ CAR T cells devoid of alloreactive potential can be generated from human T-cell-derived induced pluripotent stem cells via the timed and calibrated expression of a CAR that substitutes for the T-cell receptor.
Adeno-associated viruses with size-optimized genomes encoding compact adenine base editors enable therapeutic base editing in mice at low doses and high editing efficiencies.
Tissue clearing, retrograde tracing and viral gene delivery to target sites in pancreas-innervating ganglia in mice facilitate the mapping and activation of pancreatic nerves and the study of how they regulate glucose metabolism.
A paper-based assay leveraging nucleic acid strand-displacement reactions and the enzymatic amplification of the recognition of viral RNA at the single-nucleotide level allows for the rapid colorimetric detection of SARS-CoV-2 variants.
Large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess amyloid-β deposits in transgenic mouse models of Alzheimer’s disease.
The flux of autophagosomes in the heart tissue of mice can be imaged via the intravenous injection of iron oxide nanoparticles decorated with fluorescent peptides cleavable by lysosomal cathepsins.
The encapsulation of antibiotics in glucosylated polymeric nanoparticles that are readily absorbed by the proximal small intestine improves the bioavailability of the antibiotics and limits their exposure to flora in the large intestine.
An inhalable virus-like-particle consisting of exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain is stable at room temperature and elicits systemic and mucosal immune responses in small animals.
A polymer patch that rapidly and robustly adheres to diabetic wounds and contracts in a pre-programmed manner promotes wound closure and re-epithelialization, as shown in mouse and human skin, in mini-pigs and in humanized mice.
A human intestine-on-a-chip lined by intestinal epithelium derived from patients with environmental enteric dysfunction and cultured in nutrient-deficient medium recapitulates essential features of intestinal dysfunction associated with the disease.
Screening a large barcoded library of unique CD19-specific chimaeric antigen receptors with diverse intracellular domains allows for the discovery of receptors that elicit enhanced antitumoural functions.
Synthetically generated and clonally expanded libraries of immune cells displaying diverse repertoires of chimaeric antigen receptors lead to long-lasting and potent antitumour responses in mouse models of epithelial tumours.
SARS-CoV-2 and its variants can be visually detected via easy-to-use Cas13-based nucleic acid tests leveraging lyophilised reagents and fast sample inactivation at ambient temperature.
A wearable array of microneedle-based sensors can be used to wirelessly measure the levels of glucose simultaneously with those of alcohol or lactate in the interstitial fluid of volunteers performing common daily activities.