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A wide-field fluorescence microscope leveraging a spinning disc and high-speed cameras enables the recording of neural activities and neutrophil trajectories at micrometric resolution on curved cortical surfaces in live mice.
Optimized base editors targeting the exon-7 mutation in SMN2 restore expression of the survival motor neuron (SMN) protein to normal levels, as shown in mice with spinal muscular atrophy and in fibroblasts from patients with this genetic disease.
A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.
The transplantation and long-term survival of hydrogel-encapsulated islets can be enhanced by first using a catheter to create a subcutaneous cavity and to trigger inflammation-induced local neovascularization.
A subcutaneous colon-specific niche consisting of colon epithelial cells, decellularized colon extracellular matrix and immunosuppressive nanofibres reduced inflammation in the gastrointestinal tract of mice with established ulcerative colitis.
Skin-microangiopathy phenotypes can be correlated with diabetes stage by leveraging clinically explainable morphophysiological features obtained from the analysis, via machine learning, of raster-scan optoacoustic mesoscopy images of skin on the leg.
Photoacoustic tomography using a single laser pulse and a single element functioning as thousands of virtual detectors allows for the volumetric capture of fast haemodynamic changes in the feet of human volunteers.
Barcoding individual cells with microparticles emitting near-infrared laser light enables the use of flow cytometry for the measurement of time-resolved single-cell dynamics with more markers and fewer colours.
Replacing the extracellular domains of heterodimeric cytokine receptors in chimeric antigen receptor T cells with two leucine zipper motifs leads to optimal JAK/STAT signalling and augments the effector function of the T cells.
Successive single-shot wide-field photoacoustic images can be used to estimate the speed and direction of blood flow at more than 5 mm deep from the skin’s surface.
Metabolic rewiring during tachycardia promotes tissue hypoxia, elevated glucose utilization and the suppression of oxidative phosphorylation, driving contractile dysfunction.
The immunization of mice with colitis with self-assembling supramolecular peptide nanofibres bearing phosphorylcholine epitopes induced sustained levels of anti-phosphorylcholine antibodies that were both protective and therapeutic.
A high-throughput microfluidic method for the analysis of the secretion levels of large populations of immune cells allows for the identification of kinase-coding genes regulating interferon-gamma secretion by CD4+ T cells.
Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting domains and fusogenic glycoproteins.
Gold-nanoparticle-coated titania nanowire arrays subretinally implanted in blind mice and monkeys offer advantages in visual acuity and contrast sensitivity towards the restoration of visual function.
The overexpression of eight immunomodulatory transgenes in mouse embryonic stem cells allows these immunologically ‘cloaked’ cells as well as tissues derived from them to escape rejection and to survive for months in immunocompetent allogeneic recipients.
High-throughput methods based on droplet microfluidics and size-exclusion selection allow for the identification of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 and of inhibitors of such cell–cell fusion.
Replacing amino acid residues in an immunodominant and conserved T-cell epitope in the capsid of an adeno-associated virus widely used in gene therapies abrogates its immunogenicity while preserving its function and potency.
A fluorescence-based assay that leverages the enzyme Cas12a to transduce and amplify cumulative forces generated by cells allows for the quantification of platelet dysfunction, as shown with patients who had undergone cardiopulmonary bypass.
Two optogenetic methods for vagus-nerve stimulation, via the selective expression of opsins in either subdiaphragmatic or pancreas-innervating nerve fibres, led to enhanced glucose-stimulated insulin secretion and β cell proliferation in mice.