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Introducing GenomeNet-Architect, a neural architecture design framework that automatically optimises the overall layout of the architecture, the hyperparameters, and the training procedure of deep learning models for genome sequence data.
Proteomic study of mild hypothermia in skeletal muscle myoblasts from mice shows that hypothermia enhances mitochondrial metabolism and differentiation via the cold shock protein RBM3 and its overexpression even at room temperature can recapitulate these effects.
A study about the development of a quantitative agent-based model of yeast colony growth reproducing colony size measurements at various environmental conditions, like altered humidity, nutrient gradients, or varied initial colony inoculation.
Neoantigens derived from somatic mutations in KRAS represent promising targets for cancer immunotherapy. Through structure-based design, the authors identify the KRAS-G12V specific affinity-enhanced TCR, offering great promise for advancing cancer immunotherapy.
Snow avalanches—a direct physical process—represent a major source of mortality and comprise a previously undescribed pathway by which climate-linked mechanisms impact demographics of slow-growing populations of mountain-adapted animals.
Single molecule diffusion study to determine the impact of (poly)ribosome distribution, cell aging, protein aggregation, and biomolecular condensate formation on the spatial organization and mobility of proteins in bacteria.
A study on cryo-EM structural analysis of AFP, including N-glycosylation, fatty acids, and metal ion binding sites, and a systematic comparison with HSA.
A study using intracranial recordings in humans suggests that upcoming hand movements can be predicted by oscillatory brain features of the LFP signal.
A dominate modifier screen in Drosophila identifies transcriptional regulators that control expression of DIP-α, a cell surface protein, and synaptic target recognition in the neuromuscular system.
GWAS meta-analysis associates 12 sequence variants with essential tremor, identifies seven candidate causal genes including CA3 with multiomics-based analysis, and reveals key roles of dopaminergic and GABAergic neurons in the pathogenesis.
The T4SS of RP4, a well-known conjugative plasmid in Gram-negative bacteria, displays a lethal phenotype that is independent of DNA transfer or translocated molecules and is capable of eliminating a range of Gram-negative bacterial species.
Regulation of siderophore biosynthesis in Shewanella occurs at both transcriptional and post-transcriptional levels by two TCSs, one of which is composed of an orphan phosphorylation-independent RR functioning via a novel mechanism.
G protein-coupled receptors oscillate between inactive and active states, resulting in constitutive activity. Here we show that the calcium-sensing receptor is strongly maintained in the inactive state, resulting in undetectable constitutive activity.
Next-Generation Sequencing and analysis of 16 S rRNA gene from Bengali, Chakma, Marma, Khyang, and Tripura fecal samples revealed a distinct diversity profile of their gut microbiota compared to that of other countries.
A single-cell RNA sequencing reference of six treatment naïve canine osteosarcoma samples. The data presented in this study reveals the presence of 41 cell types and suggests a conserved tumor microenvironment between canine and human osteosarcoma.
The chemokine receptors CCR2 and CCR7 synergistically regulate recruitment of inflammatory monocytes from the bone marrow to the brain of mice infected with La Crosse and Herpes Simplex virus.
A genome-wide CRISPR/Cas9 screen in osimertinib-treated EGFR mutant cell lines identifies the Hippo pathway as an important non-genetic mechanism of cell survival in persister cells.