Protein degradation in disease
- Submission status
- Open
- Submission deadline
Protein homeostasis is vital for healthy cells. It enables cells to rapidly initiate and terminate signaling pathways and allows for cell proliferation, growth, and differentiation. Disruption of this process is associated with disease, leading to aberrant signaling cascades, accumulation of protein aggregates, and proteotoxicity. Protein degradation is an important part of regulating proteostasis, and this complex process is mediated by a host of intracellular factors, many of which are deregulated in disease. Understanding this interconnected network and how to best target malfunctioning factors can help identify novel therapeutics for multiple disease types, such as neurodegenerative diseases and cancer.
This Collection is aimed at improving our understanding of protein degradation in disease and is open to original research examining protein degradation in a disease setting.
Editors
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Aldrin V. Gomes, PhD
University of California, Davis, USA
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Yufeng Tong, PhD
University of Windsor, Canada
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Kwon-Yul Ryu, PhD
University of Seoul, South Korea
Aldrin V. Gomes, Ph.D., University of California, Davis, USA
Aldrin V. Gomes is a Professor of Neurobiology, Physiology, and Behavior at the University of California, Davis, USA. His research activities include investigating the role of the proteasome and immunoproteasome in cardiac biology, as well as signaling pathways affected by commonly used drugs such as ibuprofen. Dr Gomes has been an Editorial Board Member for Scientific Reports since 2023.
Yufeng Tong, PhD, University of Windsor, Canada
Yufeng Tong is an Assistant Professor of Experimental Biochemistry at the University of Windsor, Canada. His research focuses on understanding the structure-function relationship of ubiquitin regulatory enzymes and small GTPases regulators. Dr Tong has been an Editorial Board Member for Scientific Reports since 2017.
Kwon-Yul Ryu, PhD, University of Seoul, South Korea
Kwon-Yul Ryu is a Professor at the Department of Life Science, University of Seoul, South Korea. His research activities include neurodegenerative diseases, reactive astrogliosis, ubiquitin-proteasome system, and autophagy-lysosome pathway. Dr Ryu has been working as an Editorial Board Member for Scientific Reports since 2015.
