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Protein degradation in disease

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Protein homeostasis is vital for healthy cells. It enables cells to rapidly initiate and terminate signaling pathways and allows for cell proliferation, growth, and differentiation. Disruption of this process is associated with disease, leading to aberrant signaling cascades, accumulation of protein aggregates, and proteotoxicity. Protein degradation is an important part of regulating proteostasis, and this complex process is mediated by a host of intracellular factors, many of which are deregulated in disease. Understanding this interconnected network and how to best target malfunctioning factors can help identify novel therapeutics for multiple disease types, such as neurodegenerative diseases and cancer.

This Collection is aimed at improving our understanding of protein degradation in disease and is open to original research examining protein degradation in a disease setting.

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Structure of 26S proteasome, 3D cartoon and Gaussian surface models, PDB 5gjr, white background

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