Cellular senescence
- Submission status
- Closed
- Submission deadline
Cellular senescence is induced by many cellular stressors and is accompanied by phenotypic changes, such as a stable proliferation arrest and the development of a pro-inflammatory secretome, also known as the senescence-associated secretory phenotype (SASP). Although the transient presence of senescent cells is beneficial in certain physiological functions, such as tumour suppression and wound healing, chronic accumulation of senescent cells in tissues has been implicated as a driver of aging and age-related diseases. Importantly, clearance of senescent cells has been shown to improve a variety of age-related pathologies. Therefore, development of therapies that target senescent cells (senotherapies) is an attractive strategy to improve organismal healthspan.
This Collection will feature articles focused on the role of cellular senescence in health and age-related diseases and will highlight the latest knowledge on the development of therapeutic strategies to target senescent cells.
This Collection supports and amplifies research related to SDG 3.
Editors
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Stella Victorelli, Ph.D
Research Associate, Assistant Professor of Physiology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
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Larissa G. Prata, Ph.D
Research Associate, Robert and Arlene Kogod Center on Aging at Mayo Clinic, Rochester, Minnesota, USA.
Dr. Stella Victorelli is a Research Associate and Assistant Professor in the Department of Physiology & Biomedical Engineering at Mayo Clinic, Rochester. She completed her PhD at Newcastle University (UK) in 2018, where she investigated the role on melanocyte senescence during skin aging. Following her PhD, she started an appointment as a post-doctoral researcher at Mayo Clinic as part of the Robert & Arlene Kogod Center on Aging, where she continued to investigate the mechanisms involved in aging and senescence. Her current research involves understanding the role of sub-lethal apoptotic mitochondrial stress during cellular senescence and its role in the regulation of the pro-inflammatory secretory phenotype of senescent cells. She is also interested in investigating therapeutic strategies targeting mitochondria that might translate into therapies to improve age-related diseases.
Dr. Larissa Langhi Prata, Ph.D., is a Research Associate at the Robert & Arlene Kogod Center on Aging at Mayo Clinic in Rochester, MN. She completed her bachelor's degree in biomedical science and pursued her Ph.D. in morphological sciences at the Federal University of Rio de Janeiro, where her research focused on the aging of the primary lymphoid organ, the thymus. Following her doctoral studies, Dr. Langhi Prata joined Mayo Clinic as a postdoctoral researcher, investigating the effects of senescent cell clearance through the use of senolytics in various pre-clinical models and the first human clinical trials. Her current research centers around examining the interactions between senescent cells and the immune system, and how their presence influences immune function and aging processes.
