Cellular senescence
- Submission status
- Closed
- Submission deadline
Cellular senescence is induced by many cellular stressors and is accompanied by phenotypic changes, such as a stable proliferation arrest and the development of a pro-inflammatory secretome, also known as the senescence-associated secretory phenotype (SASP). Although the transient presence of senescent cells is beneficial in certain physiological functions, such as tumour suppression and wound healing, chronic accumulation of senescent cells in tissues has been implicated as a driver of aging and age-related diseases. Importantly, clearance of senescent cells has been shown to improve a variety of age-related pathologies. Therefore, development of therapies that target senescent cells (senotherapies) is an attractive strategy to improve organismal healthspan.
This Collection will feature articles focused on the role of cellular senescence in health and age-related diseases and will highlight the latest knowledge on the development of therapeutic strategies to target senescent cells.
This Collection supports and amplifies research related to SDG 3.
Editors
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Stella Victorelli, Ph.D
Research Associate, Assistant Professor of Physiology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
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Larissa G. Prata, Ph.D
Research Associate, Robert and Arlene Kogod Center on Aging at Mayo Clinic, Rochester, Minnesota, USA.
All articles have undergone npj Aging’s standard peer review process and have been subject to all the journal’s standard policies. This includes the journal’s policy on competing interests. The Editors declare no competing interests with the submissions which they have handled through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.
If accepted for publication, an article processing charge applies (with standard waiver policy). If your institution or country has an open access agreement with Springer Nature, you may publish your article OA at no cost or in some cases with the costs partially funded (see details here).
All Collections are open for submissions from all authors – and not by invitation only – on the condition that the manuscripts fall within the scope of the Collection and of npj Aging more generally.
Manuscripts submitted to an open Collection may be considered unsuitable for inclusion, particularly if they fall outside the scope of the Collection. In such cases, the authors will be notified by the editorial office and their manuscript can be considered as a regular npj Aging submission.
npj Aging’s in-house editors reserve the right to assume responsibility for the management of a Collection at any stage.
