Featured
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Article
| Open AccessA multiplexed nanostructure-initiator mass spectrometry (NIMS) assay for simultaneously detecting glycosyl hydrolase and lignin modifying enzyme activities
- Nicole Ing
- , Kai Deng
- & Trent R. Northen
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Article
| Open AccessMeasurements of the swimming speeds of motile microorganisms using object tracking and their correlation with water pollution and rheology levels
- Ashaa Preyadharishini Shunmugam
- , Gowtham Subramanian
- & Javier G. Fernandez
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Article
| Open Access1H NMR based metabolic profiling distinguishes the differential impact of capture techniques on wild bighorn sheep
- Galen O’Shea-Stone
- , Rachelle Lambert
- & Robert Garrott
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| Open AccessFaster monitoring of the invasive alien species (IAS) Dreissena polymorpha in river basins through isothermal amplification
- Joana Carvalho
- , Alejandro Garrido-Maestu
- & Marta Prado
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Article
| Open AccessPhosphopeptide interactions of the Nbs1 N-terminal FHA-BRCT1/2 domains
- Kyungmin Kim
- , Thomas W. Kirby
- & Robert E. London
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Article
| Open AccessEffects of cadmium stress on physiological indexes and fruiting body nutritions of Agaricus brasiliensis
- Lingyun Liu
- , Hua Chen
- & Guoxue Li
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Article
| Open AccessMaking the choice between bioelectrical impedance measures for body hydration status assessment
- Dmitry M. Davydov
- , Andrey Boev
- & Stas Gorbunov
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Article
| Open AccessProteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer
- Alberto Valdés
- , Athanasios Bitzios
- & Sara Bergström Lind
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Article
| Open AccessSupercritical-CO2 extraction, identification and quantification of polyprenol as a bioactive ingredient from Irish trees species
- Hadil Alaydi
- , Peter Downey
- & Tanya Beletskaya
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Article
| Open AccessDiscovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases
- Mariia Yu. Rybak
- , Anatoliy O. Balanda
- & Galyna P. Volynets
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Article
| Open AccessComparison of different protocols for demineralization of cortical bone
- Siyuan Pang
- , Frances Y. Su
- & Iwona Jasiuk
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Article
| Open AccessSerum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
- Anne-Christine Bay-Jensen
- , Asger Bihlet
- & Morten A. Karsdal
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Article
| Open AccessA facile colorimetric method for the quantification of labile iron pool and total iron in cells and tissue specimens
- Usama Abbasi
- , Srinivas Abbina
- & Jayachandran N. Kizhakkedathu
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| Open AccessGlobal multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations
- Arun Parupudi
- , Sumit K. Chaturvedi
- & Peter Schuck
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| Open AccessA novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies
- Kenta Noda
- , Kouki Matsuda
- & Akinobu Hamada
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| Open AccessComprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu
- Alberto Valdés
- , Francisco J. Lucio-Cazaña
- & María Luisa Marina
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Article
| Open AccessExtraction of short chain chitooligosaccharides from fungal biomass and their use as promoters of arbuscular mycorrhizal symbiosis
- Andrea Crosino
- , Elisa Moscato
- & Andrea Genre
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Article
| Open AccessSurface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
- Andreas Kiontke
- , Mehrzad Roudini
- & Claudia Birkemeyer
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| Open AccessApplications of cell resealing to reconstitute microRNA loading to extracellular vesicles
- Yuki Sonoda
- , Fumi Kano
- & Masayuki Murata
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| Open AccessEnhanced fatty acid methyl esters recovery through a simple and rapid direct transesterification of freshly harvested biomass of Chlorella vulgaris and Messastrum gracile
- Saw Hong Loh
- , Mee Kee Chen
- & Thye San Cha
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Article
| Open AccessEnzyme and lateral flow monoclonal antibody-based immunoassays to simultaneously determine spirotetramat and spirotetramat-enol in foodstuffs
- Ramón E. Cevallos-Cedeño
- , Consuelo Agulló
- & Josep V. Mercader
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Article
| Open AccessDistribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
- Yuki Takemoto
- , Chihiro Kishi
- & Nobuhiro Zaima
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Article
| Open AccessThermal transformation of polar into less-polar ginsenosides through demalonylation and deglycosylation in extracts from ginseng pulp
- Fan Yao
- , Xiang Li
- & Yujun Liu
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Article
| Open AccessSearching for a UV-filter in the eyes of high-flying birds
- Malgorzata Zawadzka
- , Beatrix Ràcz
- & Steven Ray Wilson
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Article
| Open AccessBioavailable fluoride in calcium-containing dentifrices
- Peiyan Shen
- , James R. Fernando
- & Eric C. Reynolds
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Article
| Open AccessValidation and assessment of preanalytical factors of a fluorometric in vitro assay for glucocerebrosidase activity in human cerebrospinal fluid
- Linn Oftedal
- , Jodi Maple-Grødem
- & Johannes Lange
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Article
| Open AccessBioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells
- Patrick Hardinge
- , Divesh K. Baxani
- & Oliver K. Castell
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| Open AccessCu-chitosan nano-net improves keeping quality of tomato by modulating physio-biochemical responses
- Mahendra Meena
- , Shalini Pilania
- & Vinod Saharan
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| Open AccessRapid microbial identification and colistin resistance detection via MALDI-TOF MS using a novel on-target extraction of membrane lipids
- Matthew Sorensen
- , Courtney E. Chandler
- & Erik Nilsson
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Article
| Open AccessSpectral fingerprinting to evaluate effects of storage conditions on biomolecular structure of filter-dried saliva samples and recovered DNA
- Raffaele Brogna
- , Harriëtte Oldenhof
- & Willem F. Wolkers
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Article
| Open AccessHuman volunteer study of the decontamination of chemically contaminated hair and the consequences for systemic exposure
- Samuel Collins
- , Thomas James
- & Richard Amlôt
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Article
| Open AccessCross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study
- Andrew McGarry
- , John Gaughan
- & Ruin Moaddel
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| Open AccessA serological assay to detect SARS-CoV-2 antibodies in at-home collected finger-prick dried blood spots
- Donna Grace Karp
- , Kenneth Danh
- & Cheng-ting Tsai
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Article
| Open AccessCharacterisation of the main PSA glycoforms in aggressive prostate cancer
- Anna Gratacós-Mulleras
- , Adrià Duran
- & Rosa Peracaula
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Article
| Open AccessCleavable hairpin beacon-enhanced fluorescence detection of nucleic acid isothermal amplification and smartphone-based readout
- Xiong Ding
- , Kun Yin
- & Changchun Liu
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| Open AccessModified aptamers as reagents to characterize recombinant human erythropoietin products
- Wojciech Jankowski
- , H. A. Daniel Lagassé
- & Zuben E. Sauna
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Article
| Open AccessFluorescent enzyme-coupled activity assay for phenylalanine ammonia-lyases
- Mădălina E. Moisă
- , Diana A. Amariei
- & László C. Bencze
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Article
| Open AccessQuantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells
- Syunsuke Yamamoto
- , Shin-ichi Matsumoto
- & Hideki Hirabayashi
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Article
| Open AccessPhosphatidylethanolamine-phosphatidylserine binding synergy of seven coagulation factors revealed using Nanodisc arrays on silicon photonic sensors
- Sara M. Medfisch
- , Ellen M. Muehl
- & Ryan C. Bailey
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Article
| Open AccessHomogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases
- Kari Kopra
- , Iraida Sharina
- & Harri Härmä
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| Open AccessAn optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells
- Taolin Yuan
- , Jaap Keijer
- & Vincent C. J. de Boer
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Article
| Open AccessRapid detection of cytochrome cd1-containing nitrite reductase encoding gene nirS of denitrifying bacteria with loop-mediated isothermal amplification assay
- Xuzhi Zhang
- , Qianqian Yang
- & Keming Qu
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Article
| Open AccessPolystyrene adsorbents: rapid and efficient surrogate for dialysis in membrane protein purification
- Santosh Kumar Palanirajan
- , Punitha Govindasamy
- & Sathyanarayana N. Gummadi
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Article
| Open AccessA lectin-coupled porous silicon-based biosensor: label-free optical detection of bacteria in a real-time mode
- Mona Yaghoubi
- , Fereshteh Rahimi
- & Azizollah Shafiekhani
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Article
| Open AccessPredominant synthesis of giant myofibrillar proteins in striated muscles of the long-tailed ground squirrel Urocitellus undulatus during interbout arousal
- Svetlana Popova
- , Anna Ulanova
- & Ivan Vikhlyantsev
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Article
| Open AccessDefining diagnostic cutoffs in neurological patients for serum very long chain fatty acids (VLCFA) in genetically confirmed X-Adrenoleukodystrophy
- Tim W. Rattay
- , Maren Rautenberg
- & Andreas Peter
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| Open AccessComprehensive profiling of Asian and Caucasian meibomian gland secretions reveals similar lipidomic signatures regardless of ethnicity
- Igor A. Butovich
- , Tomo Suzuki
- & Seher Yuksel
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| Open AccessThe influence of proline isomerization on potency and stability of anti-HIV antibody 10E8
- Miklos Guttman
- , Neal N. Padte
- & Kelly K. Lee
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Editorial
| Open AccessSmall-volume point-of-care analytical methods
Detecting clinically relevant diagnostic biomarkers, suitable for point-of-care detection, may facilitate rapid treatment and prevention of disease. However, medical diagnosis for which there are limited quantities of testable tissue or fluid, require point-of-care technologies with superior sensitivity and specificity. The purpose of this Editorial is to provide an overview of the Collection’s content, comprising original research into fluidics-based diagnostic platforms—specifically those made of paper or other low-cost materials, that can suitably operate with tiny sample volumes from mL to nL. In particular, we will focus on the clinical applications of such research, with potential uses in a number of fields including combating the COVID-19 pandemic for instance.
- Chao-Min Cheng