News & Views |
Featured
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Article
| Open AccessP-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis
Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma.
- Daniel E. Tylawsky
- , Hiroto Kiguchi
- & Daniel A. Heller
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Perspective |
Obstacles and opportunities in a forward vision for cancer nanomedicine
This Perspective discusses biological barriers that have limited clinical translation of cancer nanomedicines and elaborates on new directions for the field that capitalize on a deeper understanding of the nano–bio interface.
- Irene de Lázaro
- & David J. Mooney
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News & Views |
Just dose it
A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.
- Twan Lammers
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Article |
Metabolic labeling and targeted modulation of dendritic cells
Dendritic cells concentrated in vivo within a hydrogel have been metabolically tagged with azido groups to enable tracking as well as delivery of antigens, adjuvants and cytokines, thereby facilitating targeted immunomodulation.
- Hua Wang
- , Miguel C. Sobral
- & David J. Mooney
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